Klionsky, Daniel JDaniel JKlionskyPetroni, GiuliaGiuliaPetroniAmaravadi, Ravi KRavi KAmaravadiBaehrecke, Eric HEric HBaehreckeBallabio, AndreaAndreaBallabioBoya, PatriciaPatriciaBoyaBravo-San Pedro, José ManuelJosé ManuelBravo-San PedroCadwell, KenKenCadwellCecconi, FrancescoFrancescoCecconiChoi, Augustine M KAugustine M KChoiChoi, Mary EMary EChoiChu, Charleen TCharleen TChuCodogno, PatricePatriceCodognoColombo, Maria IsabelMaria IsabelColomboCuervo, Ana MariaAna MariaCuervoDeretic, VojoVojoDereticDikic, IvanIvanDikicElazar, ZvulunZvulunElazarEskelinen, Eeva-LiisaEeva-LiisaEskelinenFimia, Gian MariaGian MariaFimiaGewirtz, David ADavid AGewirtzGreen, Douglas RDouglas RGreenHansen, MaleneMaleneHansenJäättelä, MarjaMarjaJäätteläJohansen, TerjeTerjeJohansenJuhász, GáborGáborJuhászKarantza, VassilikiVassilikiKarantzaKraft, ClaudineClaudineKraftKroemer, GuidoGuidoKroemerKtistakis, Nicholas TNicholas TKtistakisKumar, SharadSharadKumarLopez-Otin, CarlosCarlosLopez-OtinMacleod, Kay FKay FMacleodMadeo, FrankFrankMadeoMartinez, JenniferJenniferMartinezMeléndez, AliciaAliciaMeléndezMizushima, NoboruNoboruMizushimaMünz, ChristianChristianMünzPenninger, Josef MJosef MPenningerPerera, Rushika MRushika MPereraPiacentini, MauroMauroPiacentiniReggiori, FulvioFulvioReggioriRubinsztein, David CDavid CRubinszteinRyan, Kevin MKevin MRyanSadoshima, JunichiJunichiSadoshimaSantambrogio, LauraLauraSantambrogioScorrano, LucaLucaScorranoSimon, Hans-UweHans-UweSimon0000-0002-9404-7736Simon, Anna KatharinaAnna KatharinaSimonSimonsen, AnneAnneSimonsenStolz, AlexandraAlexandraStolzTavernarakis, NektariosNektariosTavernarakisTooze, Sharon ASharon AToozeYoshimori, TamotsuTamotsuYoshimoriYuan, JunyingJunyingYuanYue, ZhenyuZhenyuYueZhong, QingQingZhongGalluzzi, LorenzoLorenzoGalluzziPietrocola, FedericoFedericoPietrocola2024-10-052024-10-052021-10-01https://boris-portal.unibe.ch/handle/20.500.12422/53636Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.enaging cancer inflammation metabolic syndromes neurodegeneration600 - Technology::610 - Medicine & healtharticle10.48350/1600243445901710.15252/embj.2021108863