Lin, ZhikaiZhikaiLinStrauss, Franz J.Franz J.StraussLang, Niklaus PeterNiklaus PeterLangSculean, AntonAntonSculeanSalvi, Giovanni EdoardoGiovanni EdoardoSalviStähli, Alexandra BeatriceAlexandra BeatriceStähli2024-10-052024-10-052021-02https://boris-portal.unibe.ch/handle/20.500.12422/55698OBJECTIVE To evaluate and compare the effects of laser monotherapy with non-surgical mechanical instrumentation alone in untreated periodontitis patients. MATERIALS AND METHODS A focused question was formulated based on the Population, Intervention, Comparison, Outcome, and Study design criteria (PICOS): in patients with untreated periodontitis, does laser mono-therapy provide adjunctive effects on pocket probing depth (PPD) changes compared with non-surgical instrumentation alone? Both randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) were included. The results of the meta-analyses are expressed as weighted mean differences (WMD) and reported according to the PRISMA guidelines. RESULTS The search yielded 1268 records, out of which 8 articles could be included. With respect to PPD changes, a meta-analysis including 5 articles (n = 148) failed to identify statistically significant differences in favor of laser monotherapy for PPD change (WMD = 0.14 mm; 95% CI: - 0.04/0.32; z = 1.51; p = 0.132) nor for clinical attachment level (CAL) (WMD = 0.04 mm; 95% CI: - 0.35/0.42; z = 0.19; p = 0.850). Data on cost-effectiveness are lacking. One study reported patient-related outcome measures (PROMS). CONCLUSIONS In untreated periodontitis patients, laser monotherapy does not yield superior clinical benefits compared with non-surgical mechanical instrumentation alone. CLINICAL RELEVANCE In untreated periodontitis patients, mechanical instrumentation with hand and/or ultrasonic instruments remains the standard of care.enLaser Laser monotherapy Monotherapy Non-surgical periodontal treatment Periodontitis Systematic review600 - Technology::610 - Medicine & healtharticle10.7892/boris.1486783317037210.1007/s00784-020-03584-y