Chatzikonstantinou, ThomasThomasChatzikonstantinouKapetanakis, AnargyrosAnargyrosKapetanakisScarfò, LydiaLydiaScarfòKarakatsoulis, GeorgiosGeorgiosKarakatsoulisAllsup, DavidDavidAllsupCabrero, Alejandro AlonsoAlejandro AlonsoCabreroAndres, MartinMartinAndresAntic, DarkoDarkoAnticBaile, MónicaMónicaBaileBaliakas, PanagiotisPanagiotisBaliakasBron, DominiqueDominiqueBronCapasso, AntonellaAntonellaCapassoChatzileontiadou, SofiaSofiaChatzileontiadouCordoba, RaulRaulCordobaCorrea, Juan-GonzaloJuan-GonzaloCorreaCuéllar-García, CarolinaCarolinaCuéllar-GarcíaDe Paoli, LorenzoLorenzoDe PaoliDe Paolis, Maria RosariaMaria RosariaDe PaolisDel Poeta, GiovanniGiovanniDel PoetaDemosthenous, ChristosChristosDemosthenousDimou, MariaMariaDimouDonaldson, DavidDavidDonaldsonDoubek, MichaelMichaelDoubekEfstathopoulou, MariaMariaEfstathopoulouEichhorst, BarbaraBarbaraEichhorstEl-Ashwah, ShaimaaShaimaaEl-AshwahEnrico, AliciaAliciaEnricoEspinet, BlancaBlancaEspinetFarina, LuciaLuciaFarinaFerrari, AngelaAngelaFerrariFoglietta, MyriamMyriamFogliettaFrederiksen, HenrikHenrikFrederiksenFürstenau, MoritzMoritzFürstenauGarcía-Marco, José AJosé AGarcía-MarcoGarcía-Serra, RocíoRocíoGarcía-SerraGentile, MassimoMassimoGentileGimeno, EvaEvaGimenoGlenthøj, AndreasAndreasGlenthøjGomes da Silva, MariaMariaGomes da SilvaGutwein, OditOditGutweinHakobyan, Yervand KYervand KHakobyanHerishanu, YairYairHerishanuHernández-Rivas, José ÁngelJosé ÁngelHernández-RivasHerold, TobiasTobiasHeroldInnocenti, IdannaIdannaInnocentiItchaki, GiladGiladItchakiJaksic, OzrenOzrenJaksicJanssens, AnnAnnJanssensKalashnikova, Оlga BОlga BKalashnikovaKalicińska, ElżbietaElżbietaKalicińskaKarlsson, Linda KatharinaLinda KatharinaKarlssonKater, Arnon PArnon PKaterKersting, SabinaSabinaKerstingLabrador, JorgeJorgeLabradorLad, DeepeshDeepeshLadLaurenti, LucaLucaLaurentiLevin, Mark-DavidMark-DavidLevinLista, EnricoEnricoListaLopez-Garcia, AlbertoAlbertoLopez-GarciaMalerba, LaraLaraMalerbaMarasca, RobertoRobertoMarascaMarchetti, MoniaMoniaMarchettiMarquet, JuanJuanMarquetMattsson, MattiasMattiasMattssonMauro, Francesca RFrancesca RMauroMilosevic, IvanaIvanaMilosevicMirás, FatimaFatimaMirásMorawska, MartaMartaMorawskaMotta, MarinaMarinaMottaMunir, TalhaTalhaMunirMurru, RobertaRobertaMurruNiemann, Carsten UCarsten UNiemannRodrigues, Raquel NunesRaquel NunesRodriguesOlivieri, JacopoJacopoOlivieriOrsucci, LorellaLorellaOrsucciPapaioannou, MariaMariaPapaioannouPavlovsky, Miguel ArturoMiguel ArturoPavlovskyPiskunova, IngaIngaPiskunovaPopov, Viola MariaViola MariaPopovQuaglia, Francesca MariaFrancesca MariaQuagliaQuaresmini, GiuliaGiuliaQuaresminiQvist, KristianKristianQvistReda, GianluigiGianluigiRedaRigolin, Gian MatteoGian MatteoRigolinRuchlemer, RosaRosaRuchlemerSaghumyan, GevorgGevorgSaghumyanShrestha, AmitAmitShresthaŠimkovič, MartinMartinŠimkovičŠpaček, MartinMartinŠpačekSportoletti, PaoloPaoloSportolettiStanca, OanaOanaStancaStavroyianni, NikiNikiStavroyianniTadmor, TamarTamarTadmorTe Raa, DoreenDoreenTe RaaTonino, Sanne HSanne HToninoTrentin, LivioLivioTrentinVan Der Spek, EllenEllenVan Der Spekvan Gelder, MichelMichelvan Geldervan Kampen, RoelRoelvan KampenVarettoni, MarziaMarziaVarettoniVisentin, AndreaAndreaVisentinVitale, CandidaCandidaVitaleWasik-Szczepanek, EwaEwaWasik-SzczepanekWróbel, TomaszTomaszWróbelSan Segundo, Lucrecia YáñezLucrecia YáñezSan SegundoYassin, MohamedMohamedYassinCoscia, MartaMartaCosciaRambaldi, AlessandroAlessandroRambaldiMontserrat, EmiliEmiliMontserratFoà, RobinRobinFoàCuneo, AntonioAntonioCuneoStamatopoulos, KostasKostasStamatopoulosGhia, PaoloPaoloGhia2024-10-062024-10-062021-12https://boris-portal.unibe.ch/handle/20.500.12422/58470Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.en600 - Technology::610 - Medicine & healtharticle10.48350/1624773472545410.1038/s41375-021-01450-8