Muñoz-Martínez, SergioSergioMuñoz-MartínezSapena, VictorVictorSapenaForner, AlejandroAlejandroFornerNault, Jean-CharlesJean-CharlesNaultSapisochin, GonzaloGonzaloSapisochinRimassa, LorenzaLorenzaRimassaSangro, BrunoBrunoSangroBruix, JordiJordiBruixSanduzzi-Zamparelli, MarcoMarcoSanduzzi-ZamparelliHołówko, WacławWacławHołówkoEl Kassas, MohamedMohamedEl KassasMocan, TudorTudorMocanBouattour, MohamedMohamedBouattourMerle, PhilippePhilippeMerleHoogwater, Frederik J HFrederik J HHoogwaterAlqahtani, Saleh ASaleh AAlqahtaniReeves, Helen LHelen LReevesPinato, David JDavid JPinatoGiorgakis, EmmanouilEmmanouilGiorgakisMeyer, TimTimMeyerVilladsen, Gerda ElisabethGerda ElisabethVilladsenWege, HenningHenningWegeSalati, MassimilianoMassimilianoSalatiMínguez, BeatrizBeatrizMínguezDi Costanzo, Giovan GiuseppeGiovan GiuseppeDi CostanzoRoderburg, ChristophChristophRoderburgTacke, FrankFrankTackeVarela, MaríaMaríaVarelaGalle, Peter RPeter RGalleAlvares-da-Silva, Mario ReisMario ReisAlvares-da-SilvaTrojan, JörgJörgTrojanBridgewater, JohnJohnBridgewaterCabibbo, GiuseppeGiuseppeCabibboToso, ChristianChristianTosoLachenmayer, AnjaAnjaLachenmayerCasadei-Gardini, AndreaAndreaCasadei-GardiniToyoda, HidenoriHidenoriToyodaLüdde, TomTomLüddeVillani, RosannaRosannaVillaniMatilla Peña, Ana MaríaAna MaríaMatilla PeñaGuedes Leal, Cassia ReginaCassia ReginaGuedes LealRonzoni, MonicaMonicaRonzoniDelgado, ManuelManuelDelgadoPerelló, ChristieChristiePerellóPascual, SoniaSoniaPascualLledó, José LuisJosé LuisLledóArgemi, JosepmariaJosepmariaArgemiBasu, BristiBristiBasuda Fonseca, LeonardoLeonardoda FonsecaAcevedo, JuanJuanAcevedoSiebenhüner, Alexander RAlexander RSiebenhünerBraconi, ChiaraChiaraBraconiMeyers, Brandon MBrandon MMeyersGranito, AlessandroAlessandroGranitoSala, MargaritaMargaritaSalaRodríguez-Lope, CarlosCarlosRodríguez-LopeBlaise, LorraineLorraineBlaiseRomero-Gómez, ManuelManuelRomero-GómezPiñero, FedericoFedericoPiñeroGomez, DhannyDhannyGomezMello, VivianneVivianneMelloPinheiro Alves, Rogerio CamargoRogerio CamargoPinheiro AlvesFrança, AlexAlexFrançaBranco, FernandaFernandaBrancoBrandi, GiovanniGiovanniBrandiPereira, GustavoGustavoPereiraColl, SusannaSusannaCollGuarino, MariaMariaGuarinoBenítez, CarlosCarlosBenítezAnders, Maria MargaritaMaria MargaritaAndersBandi, Juan CJuan CBandiVergara, MercedesMercedesVergaraCalvo, MarionaMarionaCalvoPeck-Radosavljevic, MarkusMarkusPeck-RadosavljevicGarcía-Juárez, IgnacioIgnacioGarcía-JuárezCardinale, VincenzoVincenzoCardinaleLozano, MarMarLozanoGambato, MartinaMartinaGambatoOkolicsanyi, StefanoStefanoOkolicsanyiMorales-Arraez, DaliaDaliaMorales-ArraezElvevi, AlessandraAlessandraElveviMuñoz, Alberto EAlberto EMuñozLué, AlbertoAlbertoLuéIavarone, MassimoMassimoIavaroneReig, MariaMariaReig2024-09-022024-09-022021-06https://boris-portal.unibe.ch/handle/20.500.12422/43715Background & Aims The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic. Methods An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave. Results Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37). Conclusions The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making. Lay summary The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes.enBCLCBarcelona Clinic Liver Cancer CERO-19Liver Cancer Outcome in the COVID-19-pandemic Project COVID-19 COVID-19coronavirus disease 2019 Cholangiocarcinoma Clinical trials ENS-CCAEuropean Network for the Study of Cholangiocarcinoma HCChepatocellular carcinoma Hepatocellular carcinoma LCliver cancer LTliver transplantation Liver cancer Management Nurses SARS-CoV-2severe acute respiratory syndrome coronavirus-2 iCCAintrahepatic cholangiocarcinoma600 - Technology::610 - Medicine & healtharticle10.48350/1593273364472510.1016/j.jhepr.2021.100260