Burri, ChristianChristianBurriSalzmann, SimonSimonSalzmannWandel, JasminJasminWandelHoffmann, LeonieLeonieHoffmannPovažay, BorisBorisPovažayMeier, ChristophChristophMeierFrenz, MartinMartinFrenz0000-0002-6741-94342024-10-262024-10-262023-12-01https://boris-portal.unibe.ch/handle/20.500.12422/175041Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90 × 90 µm2, radiant exposure: 247 to 1975 mJ/µm2). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.en500 - Science::570 - Life sciences; biology600 - Technology::610 - Medicine & health600 - Technology::620 - Engineeringarticle10.48350/1936383842030610.1364/BOE.503941