Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form

Corazza, NadiaNadiaCorazzaBrunner, ThomasThomasBrunnerBuri, CarolineCarolineBuriRihs, SilviaSilviaRihsImboden, Martin AMartin AImbodenSeibold, IngeIngeSeiboldMüller, ChristophChristophMüller0000-0002-3921-86782024-10-142024-10-142004https://boris-portal.unibe.ch/handle/20.500.12422/110437Tumor necrosis factor (TNF) is cleaved proteolytically from a 26-kilodalton transmembrane precursor protein into secreted 17-kilodalton monomers. Transmembrane (tm) and secreted trimeric TNF are biologically active and may mediate distinct activities. We assessed the consequences of a complete inhibition of TNF processing on the course of colitis in recombination activating gene (RAG)2 -/- mice on transfer of CD4 CD45RB hi T cells.en500 - Science::570 - Life sciences; biology600 - Technology::610 - Medicine & healthTransmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted formarticle1536203700022383450001810.1053/j.gastro.2004.06.036