Damonti, LauroLauroDamontiBuetti, Niccolò Ivo Marco-AurelioNiccolò Ivo Marco-AurelioBuettiDroz, Sara ChristineSara ChristineDrozBacher, Vera UlrikeVera UlrikeBacherPabst, Thomas NiklausThomas NiklausPabstMansouri Taleghani, BehrouzBehrouzMansouri TaleghaniBärlocher, Gabriela MariaGabriela MariaBärlocherMarschall, JonasJonasMarschall0000-0002-0052-32102024-09-022024-09-022021-08https://boris-portal.unibe.ch/handle/20.500.12422/41969There is limited and conflicting information on the prevalence of the contamination of hematopoietic stem and progenitor cell products (HPCPs) and their optimal management remains unclear. We reviewed the microbial surveillance data of HPCPs collected between 01/2002 and 12/2019 for autologous transplantation at our institution to determine the prevalence of microbial contamination and the potential infectious complications among recipients. Among 3935 HPCPs, 25 (0.6%) were contaminated. Ultimately, 22 patients received contaminated grafts, with a preemptive antimicrobial therapy initiated in 6/22. None developed subsequent infectious complications. Our data suggest that microbial contamination of autologous HPCPs and associated adverse outcomes are rare.enautologous stem cell products contamination hematopoietic stem and progenitor cell products600 - Technology::610 - Medicine & health500 - Science::570 - Life sciences; biologyarticle10.48350/1560623386489510.1016/j.jhin.2021.04.006