Petropoulou, MariaMariaPetropoulouEfthimiou, OrestisOrestisEfthimiou0000-0002-0955-7572Rücker, GertaGertaRückerSchwarzer, GuidoGuidoSchwarzerFurukawa, Toshi AToshi AFurukawaPompoli, AlessandroAlessandroPompoliKoek, Huiberdina LHuiberdina LKoekDel Giovane, CinziaCinziaDel GiovaneRodondi, NicolasNicolasRodondiMavridis, DimitrisDimitrisMavridis2024-09-212024-09-212021-02-08https://boris-portal.unibe.ch/handle/20.500.12422/45412Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1520803355615510.1371/journal.pone.0246631