An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.

Hauser, Christoph VictorChristoph VictorHauser0000-0002-2413-8931Aebi, SuzanneSuzanneAebiMühlemann, KathrinKathrinMühlemann2024-10-232024-10-232004-09https://boris-portal.unibe.ch/handle/20.500.12422/136282Low-level penicillin resistance in an international Streptococcus pneumoniae serotype 19F clone emerging in Switzerland was characterized by mutations in the penicillin-binding protein PBP2x. Some isolates of this clone had evolved to higher resistance levels (penicillin MICs of 0.094 and 1 microg/ml), probably by acquisition of pbp2x fragments from local nonencapsulated pneumococci.en600 - Technology::610 - Medicine & healthAn internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.article10.7892/boris.734831532812710.1128/AAC.48.9.3563-3566.2004