Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors

Pham, HungHungPhamChen, MonicaMonicaChenLi, AihuaAihuaLiKing, JonathanJonathanKingAngst, ElianeElianeAngst0000-0003-4195-4399Dawson, David W.David W.DawsonPark, JennyJennyParkReber, Howard A.Howard A.ReberHines, O. JoeO. JoeHinesEibl, GuidoGuidoEibl2024-10-102024-10-102010https://boris-portal.unibe.ch/handle/20.500.12422/70864Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Down-regulation of PGDH contributes to PGE2 accumulation in lung and colon cancers but has not been identified in pancreatic cancer.enLoss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumorsarticle1982041900027595550000710.1097/MPA.0b013e3181baecbe