Kaijansinkko, HennaHennaKaijansinkkoBonthuis, MarjoleinMarjoleinBonthuisJahnukainen, KirsiKirsiJahnukainenHarambat, JeromeJeromeHarambatVidal, EnricoEnricoVidalBakkaloglu, Sevcan ASevcan ABakkalogluInward, CarolCarolInwardSinha, Manish DManish DSinhaRoperto, Rosa MRosa MRopertoKuehni, Claudia E.Claudia E.KuehniBiró, ErikaErikaBiróKwon, TheresaTheresaKwonMota, ConceiçãoConceiçãoMotaAdams, BrigitteBrigitteAdamsSzczepańska, MariaMariaSzczepańskaBieniaś, BeataBeataBieniaśHöcker, BrittaBrittaHöckerFomina, SvitlanaSvitlanaFominaGjerstad, Ann ChristinAnn ChristinGjerstadVondrak, KarelKarelVondrakAlpay, HarikaHarikaAlpayPlumb, Lucy ALucy APlumbHommel, KristineKristineHommelMolchanova, Maria SMaria SMolchanovaHubmann, HolgerHolgerHubmannAlonso-Melgar, AngelAngelAlonso-MelgarJager, Kitty JKitty JJagerJahnukainen, TimoTimoJahnukainen2024-12-172024-12-172025-04-03https://boris-portal.unibe.ch/handle/20.500.12422/189651Cancer and its treatment may lead to kidney injury and need for kidney replacement therapy (KRT). We identified 287 pediatric KRT patients with a malignancy history from the ESPN/ERA Registry. Of these, 197 had cancer as a primary cause of KRT (group 1) and 90 had a malignancy diagnosis before KRT (group 2). Two matched controls without malignancy were randomly selected for each patient. Data were complemented with a questionnaire. Median time to kidney transplantation (KT) from KRT initiation was 2.4 (IQR: 1.5-4.7), 1.5 (IQR: 0.4-3.3), 3.6 (IQR: 1.3-Q3 not reached), and 1.1 (IQR: 0.3-3.6) years for group 1, their controls, group 2 and their controls, respectively. Overall 10-year mortality on KRT was higher among cancer patients vs. controls in group 1: 16% vs. 9% (aHR 2.02, 95% CI: 1.21-3.37) and in group 2: 23% vs. 14% (aHR 2.32, 95% CI: 1.11-4.85). In contrast, 10-year patient survival after first KT was comparable to controls (93% vs. 96%; 100% vs. 94%, in groups 1 and 2, respectively). In summary, childhood cancer survivors' KT was delayed, their overall mortality on KRT was increased, but once transplanted, their long-term outcome was similar to other KT recipients.encancerchildrenkidney replacement therapykidney transplantationmalignancymortality600 - Technology::610 - Medicine & healtharticle10.48620/785003951575910.1016/j.ajt.2024.11.002