Eijkemans, MarianneMarianneEijkemansMommers, MoniqueMoniqueMommersHarskamp-van Ginkel, Margreet WMargreet WHarskamp-van GinkelVrijkotte, Tanja G MTanja G MVrijkotteLudvigsson, JohnnyJohnnyLudvigssonFaresjö, ÅshildÅshildFaresjöBergström, AnnaAnnaBergströmEkström, SandraSandraEkströmGrote, VeitVeitGroteKoletzko, BertholdBertholdKoletzkoBønnelykke, KlausKlausBønnelykkeEliasen, Anders UlrikAnders UlrikEliasenBager, PeterPeterBagerMelbye, MadsMadsMelbyeAnnesi-Maesano, IsabellaIsabellaAnnesi-MaesanoBaïz, NourNourBaïzBarros, HenriqueHenriqueBarrosSantos, Ana CristinaAna CristinaSantosDuijts, LiesbethLiesbethDuijtsMensink-Bout, Sara MSara MMensink-BoutFlexeder, ClaudiaClaudiaFlexederKoletzko, SibylleSibylleKoletzkoSchikowski, TamaraTamaraSchikowskiEggesbø, Merete ÅseMerete ÅseEggesbøLenters, VirissaVirissaLentersFernández-Tardón, GuillermoGuillermoFernández-TardónSubiza-Perez, MikelMikelSubiza-PerezGarcia-Aymerich, JudithJudithGarcia-AymerichLópez-Vicente, MónicaMónicaLópez-VicenteSunyer, JordiJordiSunyerTorrent, MatiesMatiesTorrentBallester, FerranFerranBallesterKelleher, CecilyCecilyKelleherMehegan, JohnJohnMeheganBerg, Andrea vonAndrea vonBergHerberth, GundaGundaHerberthStandl, MarieMarieStandlKühni, ClaudiaClaudiaKühniPedersen, Eva Sophie LundeEva Sophie LundePedersen0000-0003-0293-9954Jansen, MariaMariaJansenGehring, UlrikeUlrikeGehringBoer, Jolanda M AJolanda M ABoerDevereux, GrahamGrahamDevereuxTurner, SteveSteveTurnerPeltola, VilleVillePeltolaLagström, HannaHannaLagströmInskip, Hazel MHazel MInskipPike, Katharine CKatharine CPikeDalmeijer, Geertje WGeertje WDalmeijerEnt, Cornelis K van derCornelis K van derEntThijs, CarelCarelThijs2024-10-262024-10-262024-08-15https://boris-portal.unibe.ch/handle/20.500.12422/179793OBJECTIVES To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.enAsthma Exercise Paediatric asthma600 - Technology::610 - Medicine & healtharticle10.48350/1997513914739910.1136/bmjresp-2023-001630