Schwarz, MaximilianMaximilianSchwarzPeters, AnnetteAnnettePetersStafoggia, MassimoMassimoStafoggiade'Donato, FrancescaFrancescade'DonatoSera, FrancescoFrancescoSeraBell, Michelle LMichelle LBellGuo, YumingYumingGuoHonda, YasushiYasushiHondaHuber, VeronikaVeronikaHuberJaakkola, Jouni J KJouni J KJaakkolaUrban, AlešAlešUrbanVicedo-Cabrera, Ana MariaAna MariaVicedo-CabreraMasselot, PierrePierreMasselotLavigne, EricEricLavigneAchilleos, SouzanaSouzanaAchilleosKyselý, JanJanKyselýSamoli, EvangeliaEvangeliaSamoliHashizume, MasahiroMasahiroHashizumeFook Sheng Ng, ChrisChrisFook Sheng Ngdas Neves Pereira da Silva, SusanaSusanadas Neves Pereira da SilvaMadureira, JoanaJoanaMadureiraGarland, Rebecca MRebecca MGarlandTobias, AurelioAurelioTobiasArmstrong, BenBenArmstrongSchwartz, JoelJoelSchwartzGasparrini, AntonioAntonioGasparriniSchneider, AlexandraAlexandraSchneiderBreitner, SusanneSusanneBreitner2024-10-212024-10-212024-09https://boris-portal.unibe.ch/handle/20.500.12422/47876Background Ambient air pollution, including particulate matter (such as PM and PM) and nitrogen dioxide (NO), has been linked to increases in mortality. Whether populations' vulnerability to these pollutants has changed over time is unclear, and studies on this topic do not include multicountry analysis. We evaluated whether changes in exposure to air pollutants were associated with changes in mortality effect estimates over time. Methods We extracted cause-specific mortality and air pollution data collected between 1995 and 2016 from the Multi-Country Multi-City (MCC) Collaborative Research Network database. We applied a two-stage approach to analyse the short-term effects of NO, PM, and PM on cause-specific mortality using city-specific time series regression analyses and multilevel random-effects meta-analysis. We assessed changes over time using a longitudinal meta-regression with time as a linear fixed term and explored potential sources of heterogeneity and two-pollutant models. Findings Over 21·6 million cardiovascular and 7·7 million respiratory deaths in 380 cities across 24 countries over the study period were included in the analysis. All three air pollutants showed decreasing concentrations over time. The pooled results suggested no significant temporal change in the effect estimates per unit exposure of PM, PM, or NO and mortality. However, the risk of cardiovascular mortality increased from 0·37% (95% CI -0·05 to 0·80) in 1998 to 0·85% (0·55 to 1·16) in 2012 with a 10 μg/m increase in PM. Two-pollutant models generally showed similar results to single-pollutant models for PM fractions and indicated temporal differences for NO. Interpretation Although air pollution levels decreased during the study period, the effect sizes per unit increase in air pollution concentration have not changed. This observation might be due to the composition, toxicity, and sources of air pollution, as well as other factors, such as socioeconomic determinants or changes in population distribution and susceptibility. Funding None.en600 - Technology::610 - Medicine & healtharticle10.48620/364093924378110.1016/S2542-5196(24)00168-2