Franceschini, NoraNoraFranceschiniGiambartolomei, ClaudiaClaudiaGiambartolomeide Vries, Paul SPaul Sde VriesFinan, ChrisChrisFinanBis, Joshua CJoshua CBisHuntley, Rachael PRachael PHuntleyLovering, Ruth CRuth CLoveringTajuddin, Salman MSalman MTajuddinWinkler, Thomas WThomas WWinklerGraff, MisaMisaGraffKavousi, MaryamMaryamKavousiDale, CarolineCarolineDaleSmith, Albert VAlbert VSmithHofer, EdithEdithHofervan Leeuwen, Elisabeth MElisabeth Mvan LeeuwenNolte, Ilja MIlja MNolteLu, LingyiLingyiLuScholz, MarkusMarkusScholzSargurupremraj, MuralidharanMuralidharanSargurupremrajPitkänen, NiinaNiinaPitkänenFranzén, OscarOscarFranzénJoshi, Peter KPeter KJoshiNoordam, RaymondRaymondNoordamMarioni, Riccardo ERiccardo EMarioniHwang, Shih-JenShih-JenHwangMusani, Solomon KSolomon KMusaniSchminke, UlfUlfSchminkePalmas, WalterWalterPalmasIsaacs, AaronAaronIsaacsCorrea, AdolfoAdolfoCorreaZonderman, Alan BAlan BZondermanHofman, AlbertAlbertHofmanTeumer, AlexanderAlexanderTeumerCox, Amanda JAmanda JCoxUitterlinden, André GAndré GUitterlindenWong, AndrewAndrewWongSmit, Andries JAndries JSmitNewman, Anne BAnne BNewmanBritton, AnnieAnnieBrittonRuusalepp, ArnoArnoRuusaleppSennblad, BengtBengtSennbladHedblad, BoBoHedbladPasaniuc, BogdanBogdanPasaniucPenninx, Brenda WBrenda WPenninxLangefeld, Carl DCarl DLangefeldWassel, Christina LChristina LWasselTzourio, ChristopheChristopheTzourioFava, CristianoCristianoFavaBaldassarre, DamianoDamianoBaldassarreO'Leary, Daniel HDaniel HO'LearyTeupser, DanielDanielTeupserKuh, DianaDianaKuhTremoli, ElenaElenaTremoliMannarino, ElmoElmoMannarinoGrossi, EnzoEnzoGrossiBoerwinkle, EricEricBoerwinkleSchadt, Eric EEric ESchadtIngelsson, ErikErikIngelssonVeglia, FabrizioFabrizioVegliaRivadeneira, FernandoFernandoRivadeneiraBeutner, FrankFrankBeutnerChauhan, GaneshGaneshChauhanHeiss, GerardoGerardoHeissSnieder, HaroldHaroldSniederCampbell, HarryHarryCampbellVölzke, HenryHenryVölzkeMarkus, Hugh SHugh SMarkusDeary, Ian JIan JDearyJukema, J WouterJ WouterJukemade Graaf, JacquelineJacquelinede GraafPrice, JacquelineJacquelinePricePott, JanneJannePottHopewell, Jemma CJemma CHopewellLiang, JingjingJingjingLiangThiery, JoachimJoachimThieryEngmann, JorgenJorgenEngmannGertow, KarlKarlGertowRice, KennethKennethRiceTaylor, Kent DKent DTaylorDhana, KlodianKlodianDhanaKiemeney, Lambertus A L MLambertus A L MKiemeneyLind, LarsLarsLindRaffield, Laura MLaura MRaffieldLauner, Lenore JLenore JLaunerHoldt, Lesca MLesca MHoldtDörr, MarcusMarcusDörrDichgans, MartinMartinDichgansTraylor, MatthewMatthewTraylorSitzer, MatthiasMatthiasSitzerKumari, MeenaMeenaKumariKivimaki, MikaMikaKivimakiNalls, Mike AMike ANallsMelander, OlleOlleMelanderRaitakari, OlliOlliRaitakariFranco Duran, Oscar HoracioOscar HoracioFranco DuranRueda-Ochoa, Oscar LOscar LRueda-OchoaRoussos, PanosPanosRoussosWhincup, Peter HPeter HWhincupAmouyel, PhilippePhilippeAmouyelGiral, PhilippePhilippeGiralAnugu, PramodPramodAnuguWong, QuennaQuennaWongMalik, RainerRainerMalikRauramaa, RainerRainerRauramaaBurkhardt, RalphRalphBurkhardtHardy, RebeccaRebeccaHardySchmidt, ReinholdReinholdSchmidtde Mutsert, RenéeRenéede MutsertMorris, Richard WRichard WMorrisStrawbridge, Rona JRona JStrawbridgeWannamethee, S GoyaS GoyaWannametheeHägg, SaraSaraHäggShah, SoniaSoniaShahMcLachlan, StelaStelaMcLachlanTrompet, StellaStellaTrompetSeshadri, SudhaSudhaSeshadriKurl, SudhirSudhirKurlHeckbert, Susan RSusan RHeckbertRing, SusanSusanRingHarris, Tamara BTamara BHarrisLehtimäki, TerhoTerhoLehtimäkiGalesloot, Tessel ETessel EGaleslootShah, TinaTinaShahde Faire, UlfUlfde FairePlagnol, VincentVincentPlagnolRosamond, Wayne DWayne DRosamondPost, WendyWendyPostZhu, XiaofengXiaofengZhuZhang, XiaolingXiaolingZhangGuo, XiuqingXiuqingGuoSaba, YasamanYasamanSabaDehghan, AbbasAbbasDehghanSeldenrijk, AdrieAdrieSeldenrijkMorrison, Alanna CAlanna CMorrisonHamsten, AndersAndersHamstenPsaty, Bruce MBruce MPsatyvan Duijn, Cornelia MCornelia Mvan DuijnLawlor, Deborah ADeborah ALawlorMook-Kanamori, Dennis ODennis OMook-KanamoriBowden, Donald WDonald WBowdenSchmidt, HelenaHelenaSchmidtWilson, James FJames FWilsonWilson, James GJames GWilsonRotter, Jerome IJerome IRotterWardlaw, Joanna MJoanna MWardlawDeanfield, JohnJohnDeanfieldHalcox, JulianJulianHalcoxLyytikäinen, Leo-PekkaLeo-PekkaLyytikäinenLoeffler, MarkusMarkusLoefflerEvans, Michele KMichele KEvansDebette, StéphanieStéphanieDebetteHumphries, Steve ESteve EHumphriesVölker, UweUweVölkerGudnason, VilmundurVilmundurGudnasonHingorani, Aroon DAroon DHingoraniBjörkegren, Johan L MJohan L MBjörkegrenCasas, Juan PJuan PCasasO'Donnell, Christopher JChristopher JO'Donnell2024-10-072024-10-072018-12-03https://boris-portal.unibe.ch/handle/20.500.12422/61525Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.7892/boris.1225103051015710.1038/s41467-018-07340-5