Vouga, ManonManonVougaFavre, GuillaumeGuillaumeFavreMartinez-Perez, OscarOscarMartinez-PerezPomar, LeoLeoPomarAcebal, Laura ForcenLaura ForcenAcebalAbascal-Saiz, AlejandraAlejandraAbascal-SaizHernandez, Maria Rosa VilaMaria Rosa VilaHernandezHcini, NajehNajehHciniLambert, VéroniqueVéroniqueLambertCarles, GabrielGabrielCarlesSichitiu, JoannaJoannaSichitiuSalomon, LaurentLaurentSalomonStirnemann, JulienJulienStirnemannVille, YvesYvesVillede Tejada, Begoña MartinezBegoña Martinezde TejadaGoncé, AnnaAnnaGoncéHawkins-Villarreal, AmethAmethHawkins-VillarrealCastillo, KarenKarenCastilloSolsona, Eduard GratacosEduard GratacosSolsonaTrigo, LucasLucasTrigoCleary, BrianBrianClearyGeary, MichaelMichaelGearyBartels, HelenaHelenaBartelsAl-Kharouf, FerasFerasAl-KharoufMalone, FergalFergalMaloneHiggins, MaryMaryHigginsKeating, NiamhNiamhKeatingKnowles, SusanSusanKnowlesPoncelet, ChristopheChristophePonceletRibeiro-do-Valle, Carolina CarvalhoCarolina CarvalhoRibeiro-do-ValleSurita, FernandaFernandaSuritaDantas-Silva, AmandaAmandaDantas-SilvaBorrelli, CarolinaCarolinaBorrelliLuz, Adriana GomesAdriana GomesLuzFuenzalida, JavieraJavieraFuenzalidaCarvajal, JorgeJorgeCarvajalCanales, Manuel GuerraManuel GuerraCanalesHernandez, OliviaOliviaHernandezGrechukhina, OlgaOlgaGrechukhinaKo, Albert IAlbert IKoReddy, UmaUmaReddyFigueiredo, RitaRitaFigueiredoMoucho, MarinaMarinaMouchoPinto, Pedro VianaPedro VianaPintoDe Luca, CarmenCarmenDe LucaDe Santis, MarcoMarcoDe Santisde Campos, Diogo AyresDiogo Ayresde CamposMartins, InêsInêsMartinsGarabedian, CharlesCharlesGarabedianSubtil, DamienDamienSubtilBohrer, BetaniaBetaniaBohrerDa Rocha Oppermann, Maria LuciaMaria LuciaDa Rocha OppermannWender, Maria Celeste OsorioMaria Celeste OsorioWenderSchuler-Faccini, LaviniaLaviniaSchuler-FacciniSanseverino, Maria Teresa VieiraMaria Teresa VieiraSanseverinoGiugliani, CamilaCamilaGiuglianiFriedrich, LucianaLucianaFriedrichScherer, Mariana HornMariana HornSchererMottet, NicolasNicolasMottetDucarme, GuillaumeGuillaumeDucarmePelerin, HeleneHelenePelerinMoreau, ChloeChloeMoreauBreton, BénédicteBénédicteBretonQuibel, ThibaudThibaudQuibelRozenberg, PatrickPatrickRozenbergGiannoni, EricEricGiannoniGranado, CristinaCristinaGranadoMonod, CécileCécileMonodMueller, DorisDorisMuellerHoesli, IreneIreneHoesliBassler, DirkDirkBasslerHeldstab, SandraSandraHeldstabKölble, Nicole OchsenbeinNicole OchsenbeinKölbleSentilhes, LoïcLoïcSentilhesCharvet, MelissaMelissaCharvetDeprest, JanJanDeprestRichter, JuteJuteRichterVan der Veeken, LennartLennartVan der VeekenEggel-Hort, BéatriceBéatriceEggel-HortPlantefeve, GaetanGaetanPlantefeveDerouich, MohamedMohamedDerouichCalvache, Albaro José NietoAlbaro José NietoCalvacheLopez-Giron, Maria CamilaMaria CamilaLopez-GironBurgos-Luna, Juan ManuelJuan ManuelBurgos-LunaEscobar-Vidarte, Maria FernandaMaria FernandaEscobar-VidarteHecher, KurtKurtHecherTallarek, Ann-ChristinAnn-ChristinTallarekHadar, EranEranHadarHaratz, Karina KrajdenKarina KrajdenHaratzAmikam, UriUriAmikamMalinger, GustavoGustavoMalingerMaymon, RonRonMaymonYogev, YarivYarivYogevSchäffer, LeonhardLeonhardSchäfferToussaint, ArnaudArnaudToussaintRossier, Marie-ClaudeMarie-ClaudeRossierDe Sa, Renato Augusto MoreiraRenato Augusto MoreiraDe SaGrawe, ClaudiaClaudiaGraweAebi-Popp, Karoline LieselotteKaroline LieselotteAebi-PoppRadan, Anda-PetronelaAnda-PetronelaRadanRaio, LuigiLuigiRaioSurbek, DanielDanielSurbekBöckenhoff, PaulPaulBöckenhoffStrizek, BrigitteBrigitteStrizekKaufmann, MartinMartinKaufmannBloch, AndreaAndreaBlochBoulvain, MichelMichelBoulvainJohann, SilkeSilkeJohannHeldstab, Sandra AndreaSandra AndreaHeldstabBernasconi, Monya TodescoMonya TodescoBernasconiGrant, GastonGastonGrantFeki, AnisAnisFekiBrochut, Anne-Claude MullerAnne-Claude MullerBrochutGiral, MaryleneMaryleneGiralSedille, LucieLucieSedillePapadia, AndreaAndreaPapadiaBrugger, Romina CapocciaRomina CapocciaBruggerWeber, BrigitteBrigitteWeberFischer, TinaTinaFischerKahlert, ChristianChristianKahlertSaines, Karin NielsenKarin NielsenSainesCambou, MaryMaryCambouKanellos, PanagiotisPanagiotisKanellosChen, XiangXiangChenYin, MingzhuMingzhuYinHaessig, AnninaAnninaHaessigAckermann, SandrineSandrineAckermannBaud, DavidDavidBaudPanchaud Monnat, Alice Elke MartineAlice Elke MartinePanchaud Monnat2024-09-022024-09-022021-07-06https://boris-portal.unibe.ch/handle/20.500.12422/42671Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1575233423050710.1038/s41598-021-92357-y