Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo

Shafighi, MaziarMaziarShafighiOlariu, RaduRaduOlariuFathi, Ali RezaAli RezaFathiDjafarzadeh, SiamakSiamakDjafarzadehJakob, StephanStephanJakobBanic, AndrejAndrejBanicConstantinescu, Mihai AMihai AConstantinescu2024-10-112024-10-112011https://boris-portal.unibe.ch/handle/20.500.12422/77388The goal of this study was to evaluate in vitro and in vivo the effects of up-regulation of the proangiogenic hypoxia inducible factor (HIF)-1α induced by dimethyloxalylglycine on endothelial cell cultures and on skin flap survival.enDimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivoarticle2178883300029346440003610.1097/PRS.0b013e31821e6e69