Muri, JonathanJonathanMuriCecchinato, ValentinaValentinaCecchinatoCavalli, AndreaAndreaCavalliShanbhag, Akanksha AAkanksha AShanbhagMatkovic, MilosMilosMatkovicBiggiogero, MairaMairaBiggiogeroMaida, Pier AndreaPier AndreaMaidaToscano, ChiaraChiaraToscanoGhovehoud, ElahehElahehGhovehoudDanelon-Sargenti, GabrielaGabrielaDanelon-SargentiGong, TaoTaoGongPiffaretti, PietroPietroPiffarettiBianchini, FilippoFilippoBianchiniCrivelli, VirginiaVirginiaCrivelliPodešvová, LucieLuciePodešvováPedotti, MattiaMattiaPedottiJarrossay, DavidDavidJarrossaySgrignani, JacopoJacopoSgrignaniThelen, SylviaSylviaThelenUhr, MarioMarioUhrBernasconi, EnosEnosBernasconiRauch, AndriAndriRauch0000-0001-5297-6062Manzo, AntonioAntonioManzoCiurea, AdrianAdrianCiureaRocchi, Marco B LMarco B LRocchiVarani, LucaLucaVaraniMoser, BernhardBernhardMoserThelen, MarcusMarcusThelenGarzoni, ChristianChristianGarzoniFranzetti-Pellanda, AlessandraAlessandraFranzetti-PellandaUguccioni, MariagraziaMariagraziaUguccioniRobbiani, Davide FDavide FRobbiani2024-10-112024-10-112022-05-23https://boris-portal.unibe.ch/handle/20.500.12422/85570Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 and autoimmune disorders, but they target different chemokines than those in COVID-19. Finally, monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential. One-Sentence Summary Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and are predictive of lack of long COVID.en600 - Technology::610 - Medicine & healthworking_paper10.48350/1706103566499310.1101/2022.05.23.493121