Kjær, Maj-Brit NørregaardMaj-Brit NørregaardKjærMeyhoff, Tine SylvestTine SylvestMeyhoffSivapalan, PraleenePraleeneSivapalanGranholm, AndersAndersGranholmHjortrup, Peter BuhlPeter BuhlHjortrupMadsen, Martin BruunMartin BruunMadsenMøller, Morten HylanderMorten HylanderMøllerEgerod, IngridIngridEgerodWetterslev, JørnJørnWetterslevLange, TheisTheisLangeCronhjort, MariaMariaCronhjortLaake, Jon HenrikJon HenrikLaakeJakob, StephanStephanJakobNalos, MarekMarekNalosOstermann, MarliesMarliesOstermannGould, DougDougGouldCecconi, MaurizioMaurizioCecconiMalbrain, Manu L N GManu L N GMalbrainAhlstedt, ChristianChristianAhlstedtKiel, Louise BendixLouise BendixKielBestle, Morten HMorten HBestleNebrich, LarsLarsNebrichHildebrandt, ThomasThomasHildebrandtRussell, LeneLeneRussellVang, MarianneMarianneVangRasmussen, Michael LindhartMichael LindhartRasmussenSølling, ChristofferChristofferSøllingBrøchner, Anne CraveiroAnne CraveiroBrøchnerKrag, MetteMetteKragPfortmüller, CarmenCarmenPfortmüllerKriz, MiroslavMiroslavKrizSiegemund, MartinMartinSiegemundAlbano, GiovanniGiovanniAlbanoAagaard, Søren RosborgSøren RosborgAagaardBundgaard, HelleHelleBundgaardCrone, VeraVeraCroneWichmann, SineSineWichmannJohnstad, BrorBrorJohnstadMartin, Yvonne KarinYvonne KarinMartinSeidel, PhilippPhilippSeidelMårtensson, JohanJohanMårtenssonHollenberg, JacobJacobHollenbergWistrand, MatsMatsWistrandDonati, AbeleAbeleDonatiBarbara, EnricoEnricoBarbaraKarvunidis, ThomasThomasKarvunidisHollinger, AlexaAlexaHollingerCarsetti, AndreaAndreaCarsettiLumlertgul, NutthaNutthaLumlertgulJoelsson-Alm, EvaEvaJoelsson-AlmLambiris, NikolasNikolasLambirisAslam, Tayyba NazTayyba NazAslamFriberg, Fredrik FemtehjellFredrik FemtehjellFribergVesterlund, Gitte KingoGitte KingoVesterlundMortensen, Camilla BekkerCamilla BekkerMortensenVestergaard, Stine RomStine RomVestergaardCaspersen, Sidsel FjordbakSidsel FjordbakCaspersenJensen, Diana BertelsenDiana BertelsenJensenBorup, MortenMortenBorupRasmussen, Bodil SteenBodil SteenRasmussenPerner, AndersAndersPerner2024-10-252024-10-252023-07https://boris-portal.unibe.ch/handle/20.500.12422/167925PURPOSE To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. METHODS We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. RESULTS Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) - 4.8 to 7.8]. Mean differences were 0.00 (99% CI - 0.06 to 0.05) for EQ-5D-5L index values, - 0.65 for EQ VAS (- 5.40 to 4.08), and - 0.14 for Mini MoCA (- 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. CONCLUSIONS Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.enCognitive function Critical illness Intravenous fluid Long-term outcomes Quality of life Sepsis Septic shock600 - Technology::610 - Medicine & healtharticle10.48350/1835163733092810.1007/s00134-023-07114-8