Hibar, Derrek P.Derrek P.HibarHieab, H.H. AdamsH.H. AdamsHieabChauhan, GaneshGaneshChauhanStein, Jason L.Jason L.SteinHofer, EdithEdithHoferRenteria, Miguel E.Miguel E.RenteriaBis, JoshuaJoshuaBisArias-Vasquez, AlejandroAlejandroArias-VasquezIkram, KamranKamranIkramDesrivières, SylvaneSylvaneDesrivièresVernooij, Meike W.Meike W.VernooijAbramovic, LucijaLucijaAbramovicAlhusaini, SaudSaudAlhusainiAmin, NajafNajafAminAndersson, MicaelMicaelAnderssonArfanakis, Konstantinos A.Konstantinos A.ArfanakisAribisala, Benjamin S.Benjamin S.AribisalaArmstrong, Nicola J.Nicola J.ArmstrongAthanasiu, LaviniaLaviniaAthanasiuAxelsson, TomasTomasAxelssonBeecham, Ashley H.Ashley H.BeechamBeiser, AlexaAlexaBeiserBernard, ManonManonBernardBlanton, Susan H.Susan H.BlantonBohlken, Marc M.Marc M.BohlkenBoks, Marco P.Marco P.BoksBralten, JanitaJanitaBraltenBrickman, Adam M.Adam M.BrickmanCarmichael, OwenOwenCarmichaelChakravarty, M. MallarM. MallarChakravartyChen, QiangQiangChenChing, Christopher R.K.Christopher R.K.ChingChouraki, VincentVincentChourakiCuellar-Partida, GabrielGabrielCuellar-PartidaCrivello, FabriceFabriceCrivelloDen Braber, AnoukAnoukDen BraberDoan, Nhat TrungNhat TrungDoanEhrlich, StefanStefanEhrlichGiddaluru, SudheerSudheerGiddaluruGoldman, Aaron L.Aaron L.GoldmanGottesman, Rebecca F.Rebecca F.GottesmanGrimm, OliverOliverGrimmGriswold, Michael E.Michael E.GriswoldGuadalupe, TulioTulioGuadalupeGutman, Boris A.Boris A.GutmanHass, JohannaJohannaHassHaukvik, Unn K.Unn K.HaukvikHöhn, DavidDavidHöhnHolmes, Avram J.Avram J.HolmesHoogman, MartineMartineHoogmanJanowitz, DeborahDeborahJanowitzJia, TianyeTianyeJiaJørgensen, Kjetil N.Kjetil N.JørgensenKarbalai, NazaninNazaninKarbalaiKasperaviciute, DaliaDaliaKasperaviciuteKim, SungeunSungeunKimKlein, MariekeMariekeKleinKraemer, BerndBerndKraemerLee, Phil H.Phil H.LeeLiewald, David C.M.David C.M.LiewaldLopez, Lorna M.Lorna M.LopezLuciano, MichelleMichelleLucianoMacare, ChristineChristineMacareMarquand, AndreAndreMarquandMatarin, MarMarMatarinMather, Karen A.Karen A.MatherMattheisen, ManuelManuelMattheisenMcKay, David R.David R.McKayMilaneschi, YuriYuriMilaneschiMunoz Maniega, SusannaSusannaMunoz ManiegaNho, KwangsikKwangsikNhoNugent, Allison C.Allison C.NugentNyquist, PaulPaulNyquistOlde Loohuis, Loes M.Loes M.Olde LoohuisOosterlaan, JaapJaapOosterlaanPapmeyer, MartinaMartinaPapmeyerPirpamer, LukasLukasPirpamerPütz, BennoBennoPützRamasamy, AdaikalavanAdaikalavanRamasamyRichards, Jennifer S.Jennifer S.RichardsRisacher, Shannon L.Shannon L.RisacherRoiz-Santianez, RobertoRobertoRoiz-SantianezRommelse, NandaNandaRommelseRopele, StefanStefanRopeleRose, Emma J.Emma J.RoseRoyle, Natalie A.Natalie A.RoyleRundek, TatjanaTatjanaRundekSämann, Philipp G.Philipp G.SämannSaremi, ArvinArvinSaremiSatizabal, Claudia L.Claudia L.SatizabalSchmaal, LianneLianneSchmaalSchork, Andrew J.Andrew J.SchorkShen, LiLiShenShin, JeanJeanShinShumskaya, ElenaElenaShumskayaSmith, Albert V.Albert V.SmithSprooten, EmmaEmmaSprootenStrike, Lachlan T.Lachlan T.StrikeTeumer, AlexanderAlexanderTeumerTordesillas-Gutierrez, DianaDianaTordesillas-GutierrezToro, RobertoRobertoToroTrabzuni, DaniahDaniahTrabzuniTrompet, StellaStellaTrompetVaidya, DhananjayDhananjayVaidyaVan der Grond, JeroenJeroenVan der GrondVan der Lee, Sven J.Sven J.Van der LeeVan der Meer, DennisDennisVan der MeerVan Donkelaar, Marjolein M.J.Marjolein M.J.Van DonkelaarVan Eijk, Kristel R.Kristel R.Van EijkVan Erp, Theo G.M.Theo G.M.Van ErpVan Rooij, DaanDaanVan RooijWalton, EstherEstherWaltonWestlye, Lars T.Lars T.WestlyeWhelan, Christopher D.Christopher D.WhelanWindham, Beverly G.Beverly G.WindhamWinkler, Anderson M.Anderson M.WinklerWittfeld, KatharinaKatharinaWittfeldWoldehawariat, GirmaGirmaWoldehawariatWolf, ChristianeChristianeWolfWolfers, ThomasThomasWolfersYanek, Lisa R.Lisa R.YanekYang, JingyunJingyunYangZijdenbos, AlexAlexZijdenbosZwiers, Marcel P.Marcel P.ZwiersAgartz, IngridIngridAgartzAlmasy, LauraLauraAlmasyAmes, DavidDavidAmesAmouyel, PhilippePhilippeAmouyelAndreassen, Ole A.Ole A.AndreassenArepalli, SampathSampathArepalliAssareh, Amelia A.Amelia A.AssarehBarral, SandraSandraBarralBastin, Mark E.Mark E.BastinBecker, Diane M.Diane M.BeckerBecker, James T.James T.BeckerBennett, David A.David A.BennettBlangero, JohnJohnBlangerovan Bokhoven, HansHansvan BokhovenBoomsma, Dorret I.Dorret I.BoomsmaBrodaty, HenryHenryBrodatyBrouwer, Rachel M.Rachel M.BrouwerBrunner, Han G.Han G.BrunnerBuckner, Randy L.Randy L.BucknerBuitelaar, Jan K.Jan K.BuitelaarBulayeva, Kazima B.Kazima B.BulayevaCahn, WiepkeWiepkeCahnCalhoun, Vince D.Vince D.CalhounCannon, Dara M.Dara M.CannonCavalleri, Gianpiero L.Gianpiero L.CavalleriCheng, Ching-YuChing-YuChengCichon, SvenSvenCichonCookson, Mark R.Mark R.CooksonCorvin, AidenAidenCorvinCrespo-Facorro, BenedictoBenedictoCrespo-FacorroCurran, Joanne E.Joanne E.CurranCzisch, MichaelMichaelCzischDale, Anders M.Anders M.DaleDavies, Gareth E.Gareth E.DaviesDe Craen, Anton J.M.Anton J.M.De CraenDe Geus, Eco J.C.Eco J.C.De GeusDe Jager, Philip L.Philip L.De JagerDe Zubicaray, Greig I.Greig I.De ZubicarayDeary, Ian J.Ian J.DearyDebette, StéphanieStéphanieDebetteDeCarli, CharlesCharlesDeCarliDelanty, NormanNormanDelantyDepondt, ChantalChantalDepondtDeStefano, AnitaAnitaDeStefanoDillman, AllissaAllissaDillmanDjurovic, SrdjanSrdjanDjurovicDonohoe, GaryGaryDonohoeDrevets, Wayne C.Wayne C.DrevetsDuggirala, RaviRaviDuggiralaDyer, Thomas D.Thomas D.DyerEnzinger, ChristianChristianEnzingerErk, SusanneSusanneErkEspeseth, ThomasThomasEspesethFedko, Iryna O.Iryna O.FedkoFernandez, GuillénGuillénFernandezFerrucci, LuigiLuigiFerrucciFisher, Simon E.Simon E.FisherFleischman, Debra A.Debra A.FleischmanFord, IanIanFordFornage, MyriamMyriamFornageForoud, Tatiana M.Tatiana M.ForoudFox, Peter T.Peter T.FoxFrancks, ClydeClydeFrancksFukunaga, MasakiMasakiFukunagaGibbs, J. RaphaelJ. RaphaelGibbsGlahn, David C.David C.GlahnGollub, Randy L.Randy L.GollubGöring, Harald H.H.Harald H.H.GöringGreen, Robert C.Robert C.GreenGruber, OliverOliverGruberGudnason, VilmundurVilmundurGudnasonGuelfi, SebastianSebastianGuelfiHåberg, Asta K.Asta K.HåbergHansell, Narelle K.Narelle K.HansellHardy, JohnJohnHardyHartman, Catharina A.Catharina A.HartmanHashimoto, RyotaRyotaHashimotoHegenscheid, KatrinKatrinHegenscheidHeinz, AndreasAndreasHeinzLe Hellard, StephanieStephanieLe HellardHernandez, Dena G.Dena G.HernandezHeslenfeld, Dirk J.Dirk J.HeslenfeldHo, Beng-ChoonBeng-ChoonHoHoekstra, Pieter J.Pieter J.HoekstraHoffmann, WolfgangWolfgangHoffmannHofman, AlbertAlbertHofmanHolsboer, FlorianFlorianHolsboerHomuth, GeorgGeorgHomuthHosten, NorbertNorbertHostenHottenga, Jouke-JanJouke-JanHottengaHuentelman, MatthewMatthewHuentelmanHulshoff Pol, Hilleke E.Hilleke E.Hulshoff PolIkeda, MasashiMasashiIkedaJack, Clifford R.Clifford R.JackJenkinson, MarkMarkJenkinsonJohnson, RobertRobertJohnsonJönsson, Erik G.Erik G.JönssonJukema, J. WouterJ. WouterJukemaKahn, René S.René S.KahnKanai, RyotaRyotaKanaiKloszewska, IwonaIwonaKloszewskaKnopman, David S.David S.KnopmanKochunov, PeterPeterKochunovKwok, John B.John B.KwokLawrie, Stephen M.Stephen M.LawrieLemaıtre, HervéHervéLemaıtreLiu, XinminXinminLiuLongo, Dan L.Dan L.LongoLopez, Oscar L.Oscar L.LopezLopez, Oscar L.Oscar L.LopezLovestone, SimonSimonLovestoneMartinez, OliverOliverMartinezMartinot, Jean-LucJean-LucMartinotMattay, Venkata S.Venkata S.MattayMcDonald, ColmColmMcDonaldMcIntosh, Andrew M.Andrew M.McIntoshMcMahon, Francis J.Francis J.McMahonMcMahon, Katie L.Katie L.McMahonMecocci, PatriziaPatriziaMecocciMelle, IngridIngridMelleMeyer-Lindenberg, AndreasAndreasMeyer-LindenbergMohnke, SebastianSebastianMohnkeMontgomery, Grant W.Grant W.MontgomeryMorris, Derek W.Derek W.MorrisMosley, Thomas H.Thomas H.MosleyMühleisen, Thomas W.Thomas W.MühleisenMüller-Myhsok, BertramBertramMüller-MyhsokNalls, Michael A.Michael A.NallsNauck, MatthiasMatthiasNauckNichols, Thomas E.Thomas E.NicholsNiessen, Wiro J.Wiro J.NiessenNöthen, Markus M.Markus M.NöthenNyberg, LarsLarsNybergOhi, KazutakaKazutakaOhiOlvera, Rene L.Rene L.OlveraOphoff, Roel A.Roel A.OphoffPandolfo, MassimoMassimoPandolfoPaus, TomasTomasPausPausova, ZdenkaZdenkaPausovaPenninx, Brenda W.J.H.Brenda W.J.H.PenninxPike, G. BruceG. BrucePikePotkin, Steven G.Steven G.PotkinPsaty, Bruce M.Bruce M.PsatyReppermund, SimoneSimoneReppermundRietschel, MarcellaMarcellaRietschelRoffman, Joshua L.Joshua L.RoffmanRomanczuk-Seiferth, NinaNinaRomanczuk-SeiferthRotter, Jerome I.Jerome I.RotterRyten, MinaMinaRytenSacco, Ralph L.Ralph L.SaccoS. Sachdev, PerminderPerminderS. SachdevSaykin, Andrew J.Andrew J.SaykinSchmidt, ReinholdReinholdSchmidtSchmidt, HelenaHelenaSchmidtSchofield, Peter R.Peter R.SchofieldSigursson, SigurdurSigurdurSigurssonSimmons, AndyAndySimmonsSingleton, AndrewAndrewSingletonSisodiya, Sanjay M.Sanjay M.SisodiyaSmith, ColinColinSmithSmoller, Jordan W.Jordan W.SmollerSoininen, HilkkaHilkkaSoininenSteen, Vidar M.Vidar M.SteenStott, David J.David J.StottSussmann, Jessika E.Jessika E.SussmannThalamuthu, AnbupalamAnbupalamThalamuthuToga, Arthur W.Arthur W.TogaTraynor, BryanBryanTraynorTroncoso, JuanJuanTroncosoTsolaki, MagdaMagdaTsolakiTzourio, ChristopheChristopheTzourioUitterlinden, Andre G.Andre G.UitterlindenValdés-Hernandez, Maria C.Maria C.Valdés-HernandezVan der Brug, MarcelMarcelVan der BrugVan der Lugt, AadAadVan der LugtVan der Wee, Nic J.A.Nic J.A.Van der WeeVan Haren, Neeltje E.M.Neeltje E.M.Van HarenVan’t Ent, DennisDennisVan’t EntVan Tol, Marie-JoseMarie-JoseVan TolVardarajan, Badri N.Badri N.VardarajanVellas, BrunoBrunoVellasVeltman, Dick J.Dick J.VeltmanVölzke, HenryHenryVölzkeWalter, HenrikHenrikWalterWardlaw, Joanna M.Joanna M.WardlawWassink, Thomas H.Thomas H.WassinkWeale, Michael E.Michael E.WealeWeinberger, Daniel R.Daniel R.WeinbergerWeiner, Michael W.Michael W.WeinerWen, WeiWeiWenWestman, EricEricWestmanWhite, TonyaTonyaWhiteWong, Tien Y.Tien Y.WongWright, Clinton B.Clinton B.WrightZielke, Ronald H.Ronald H.ZielkeZonderman, Alan B.Alan B.ZondermanMartin, Nicholas G.Nicholas G.MartinVan Duijn, Cornelia M.Cornelia M.Van DuijnWright, Margaret J.Margaret J.WrightLongstreth, W.T.W.T.LongstrethSchumann, GunterGunterSchumannGrabe, Hans J.Hans J.GrabeFranke, BarbaraBarbaraFrankeLauner, Lenore J.Lenore J.LaunerMedland, Sarah E.Sarah E.MedlandSeshadri, SudhaSudhaSeshadriThompson, Paul M.Paul M.ThompsonIkram, M. ArfanM. ArfanIkram2024-10-242024-10-242017https://boris-portal.unibe.ch/handle/20.500.12422/147445The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.en100 - Philosophy::150 - Psychology600 - Technology::610 - Medicine & healtharticle10.7892/boris.920752809816210.1038/ncomms13624