Larivière, SaraSaraLarivièreRodríguez-Cruces, RaúlRaúlRodríguez-CrucesRoyer, JessicaJessicaRoyerCaligiuri, Maria EugeniaMaria EugeniaCaligiuriGambardella, AntonioAntonioGambardellaConcha, LuisLuisConchaKeller, Simon SSimon SKellerCendes, FernandoFernandoCendesYasuda, ClarissaClarissaYasudaBonilha, LeonardoLeonardoBonilhaGleichgerrcht, EzequielEzequielGleichgerrchtFocke, Niels KNiels KFockeDomin, MartinMartinDominvon Podewills, FelixFelixvon PodewillsLangner, SoenkeSoenkeLangnerRummel, ChristianChristianRummelWiest, Roland Gerhard RudiRoland Gerhard RudiWiestMartin, PascalPascalMartinKotikalapudi, RavitejaRavitejaKotikalapudiO'Brien, Terence JTerence JO'BrienSinclair, BenjaminBenjaminSinclairVivash, LucyLucyVivashDesmond, Patricia MPatricia MDesmondAlhusaini, SaudSaudAlhusainiDoherty, Colin PColin PDohertyCavalleri, Gianpiero LGianpiero LCavalleriDelanty, NormanNormanDelantyKälviäinen, ReettaReettaKälviäinenJackson, Graeme DGraeme DJacksonKowalczyk, MagdalenaMagdalenaKowalczykMascalchi, MarioMarioMascalchiSemmelroch, MiraMiraSemmelrochThomas, Rhys HRhys HThomasSoltanian-Zadeh, HamidHamidSoltanian-ZadehDavoodi-Bojd, EsmaeilEsmaeilDavoodi-BojdZhang, JunsongJunsongZhangLenge, MatteoMatteoLengeGuerrini, RenzoRenzoGuerriniBartolini, EmanueleEmanueleBartoliniHamandi, KhalidKhalidHamandiFoley, SonyaSonyaFoleyWeber, BerndBerndWeberDepondt, ChantalChantalDepondtAbsil, JulieJulieAbsilCarr, Sarah J ASarah J ACarrAbela, EugenioEugenioAbelaRichardson, Mark PMark PRichardsonDevinsky, OrrinOrrinDevinskySeverino, MariasavinaMariasavinaSeverinoStriano, PasqualePasqualeStrianoTortora, DomenicoDomenicoTortoraHatton, Sean NSean NHattonVos, Sjoerd BSjoerd BVosDuncan, John SJohn SDuncanWhelan, Christopher DChristopher DWhelanThompson, Paul MPaul MThompsonSisodiya, Sanjay MSanjay MSisodiyaBernasconi, AndreaAndreaBernasconiLabate, AngeloAngeloLabateMcDonald, Carrie RCarrie RMcDonaldBernasconi, NedaNedaBernasconiBernhardt, Boris CBoris CBernhardt2024-09-022024-09-022020-11https://boris-portal.unibe.ch/handle/20.500.12422/38794Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.en600 - Technology::610 - Medicine & healtharticle10.48350/1496453320836510.1126/sciadv.abc6457