Reichmuth, Martina LarissaMartina LarissaReichmuth0000-0001-9345-851XHömke, RicoRicoHömkeZürcher, KathrinKathrinZürcherSander, PeterPeterSanderAvihingsanon, AnchaleeAnchaleeAvihingsanonCollantes, JimenaJimenaCollantesLoiseau, ChloéChloéLoiseauBorrell, SoniaSoniaBorrellReinhard, MiriamMiriamReinhardWilkinson, Robert JRobert JWilkinsonYotebieng, MarcelMarcelYotebiengFenner, LukasLukasFenner0000-0003-3309-4835Böttger, Erik CErik CBöttgerGagneux, SebastienSebastienGagneuxEgger, MatthiasMatthiasEgger0000-0001-7462-5132Keller, Peter MichaelPeter MichaelKeller0000-0002-2890-53842024-10-052024-10-052020-10-20https://boris-portal.unibe.ch/handle/20.500.12422/55317Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naïve patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical MIC to delamanid.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.7892/boris.1464063286833310.1128/AAC.00513-20