Harrell, Carl RandallCarl RandallHarrellVolarevic, AnaAnaVolarevicDjonov, Valentin GeorgievValentin GeorgievDjonov0000-0002-5062-1169Volarevic, VladislavVladislavVolarevic2024-10-062024-10-062021https://boris-portal.unibe.ch/handle/20.500.12422/57589Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.en600 - Technology::610 - Medicine & healtharticle10.48350/1612853353537610.3390/ijms22031433