Tonella, PaoloPaoloTonellaFlück Pandey, Christa EmmaChrista EmmaFlück Pandey0000-0002-4568-5504Mullis, Primus-EugenPrimus-EugenMullis2024-10-102024-10-102010https://boris-portal.unibe.ch/handle/20.500.12422/70954Growth hormone insensitivity syndrome (GHIS) is a rare cause of growth retardation characterized by high serum GH levels, and low serum insulin-like growth factor I (IGF-I) levels associated with a genetic defect of the GH receptor (GHR) as well post-GHR signaling pathway. Based on clinical, as well as biochemical characteristics, GHIS can be genetically classified as classical/Laron's syndrome and nonclassical/atypical GHIS. Recombinant human IGF-I (rhIGF-I) treatment is effective in promoting growth in subjects who have GHIS. Further, pharmacological studies of a IGF-I compound containing a 1:1 molar complex of rhIGF-I and rhIGF-binding protein-3 (BP-3) demonstrated that the complex was effective in increasing levels of circulating total and free IGF-I and that the administration in patients with GHIS should be safe, well-tolerated and more effective than rhIGF-I on its own.enarticle10.48350/1572019055200027691950000910.1159/000277660