Tomasoni, DanielaDanielaTomasoniAdamo, MariannaMariannaAdamoHausleiter, JörgJörgHausleiterPezzola, ElisaElisaPezzolaKresoja, Karl-PatrikKarl-PatrikKresojavon Stein, JenniferJennifervon SteinFortmeier, VeraVeraFortmeierPauschinger, ChristophChristophPauschingerRottbauer, WolfgangWolfgangRottbauerKassar, MohammadMohammadKassar0000-0002-7576-2224Goebel, BjoernBjoernGoebelDenti, PaoloPaoloDentiAchouh, PaulPaulAchouhRassaf, TienushTienushRassafBarreiro-Perez, ManuelManuelBarreiro-PerezBoekstegers, PeterPeterBoekstegersRück, AndreasAndreasRückZdanyte, MonikaMonikaZdanyteVincent, FlavienFlavienVincentSchlegel, PhilippPhilippSchlegelvon Bardeleben, Ralph-StephanRalph-Stephanvon BardelebenWild, Mirjam GMirjam GWildBesler, ChristianChristianBeslerBrunner, StephanieStephanieBrunnerToggweiler, StefanStefanToggweilerGrapsa, JuliaJuliaGrapsaPatterson, TiffanyTiffanyPattersonThiele, HolgerHolgerThieleKister, TobiasTobiasKisterTarantini, GiuseppeGiuseppeTarantiniMasiero, GiuliaGiuliaMasieroDe Carlo, MarcoMarcoDe CarloSticchi, AlessandroAlessandroSticchiKonstandin, Mathias HMathias HKonstandinVan Belle, EricEricVan BelleGeisler, TobiasTobiasGeislerEstévez-Loureiro, RodrigoRodrigoEstévez-LoureiroLuedike, PeterPeterLuedikeKaram, NicoleNicoleKaramMaisano, FrancescoFrancescoMaisanoLauten, PhilippPhilippLautenPraz, FabienFabienPrazKessler, MirjamMirjamKesslerKalbacher, DanielDanielKalbacherRudolph, VolkerVolkerRudolphIliadis, ChristosChristosIliadisLurz, PhilippPhilippLurzStolz, LukasLukasStolzMetra, MarcoMarcoMetra2025-07-222025-07-222025-08https://boris-portal.unibe.ch/handle/20.500.12422/213520Aims To assess the prevalence, prognostic significance, and predictors of heart failure hospitalization (HFH) before and after tricuspid transcatheter edge-to-edge repair (T-TEER) in a large real-world cohort of patients with tricuspid regurgitation (TR).Methods And Results Data from the European Registry of Transcatheter Repair for Tricuspid Regurgitation (EuroTR registry) were analysed. Among 1000 patients undergoing T-TEER for symptomatic TR, 361 (36.1%) had no HFH, 459 (45.9%) had one single HFH, and 180 (18.0%) had multiple HFH the year before T-TEER. Patients with any HFH had more severe heart failure compared with those without. Procedural success (residual TR ≤2) did not differ between patients with single, multiple, or no HFHs before T-TEER. Multivariable analysis showed that a history of HFH was associated with an increased mortality risk (adjusted hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.11-2.06 for single vs. no HFH; adjusted HR 1.63, 95% CI 1.15-2.31 for multiple vs. no HFH), and a higher risk of the combined endpoint of all-cause mortality or HFH. HFH risk decreased by 72% in the 1 year following T-TEER compared to the previous year. Procedural success was the sole independent predictor for reducing HFHs.Conclusions In the EuroTR cohort, a history of HFH was highly prevalent and associated with worse clinical outcomes. Among high-risk patients with symptomatic TR, T-TEER significantly lowered HFH risk, with residual TR grade ≤2 being the key predictor for reduced HFH incidence.enHeart failure hospitalizationMortalityTranscatheter edge‐to‐edge repairTricuspid regurgitationT‐TEER600 - Technology::610 - Medicine & healtharticle10.48620/896794067899210.1002/ejhf.3757