Dill, Michael TMichael TDillRothweiler, SonjaSonjaRothweilerDjonov, Valentin GeorgievValentin GeorgievDjonov0000-0002-5062-1169Hlushchuk, RuslanRuslanHlushchukTornillo, LuigiLuigiTornilloTerracciano, LuigiLuigiTerraccianoMeili-Butz, SilviaSilviaMeili-ButzRadtke, FreddyFreddyRadtkeHeim, Markus HMarkus HHeimSemela, DavidDavidSemela2024-10-112024-10-112012https://boris-portal.unibe.ch/handle/20.500.12422/78575Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).en600 - Technology::610 - Medicine & healthDisruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of micearticle2224584300030229640004610.1053/j.gastro.2011.12.052