Perner, AndersAndersPernerCecconi, MaurizioMaurizioCecconiCronhjort, MariaMariaCronhjortDarmon, MichaelMichaelDarmonJakob, StephanStephanJakobPettilä, VilleVillePettilävan der Horst, Iwan C CIwan C Cvan der Horst2024-10-282024-10-282018-06https://boris-portal.unibe.ch/handle/20.500.12422/180917Hypovolemia is frequent in patients with sepsis and may contribute to worse outcome. The management of these patients is impeded by the low quality of the evidence for many of the specific components of the care. In this paper, we discuss recent advances and controversies in this field and give expert statements for the management of hypovolemia in patients with sepsis including triggers and targets for fluid therapy and volumes and types of fluid to be given. Finally, we point to unanswered questions and suggest a roadmap for future research.enCritical care Fluid therapy Hemodynamics Hypovolemia Sepsis Shock600 - Technology::610 - Medicine & healtharticle10.7892/boris.1315142969629510.1007/s00134-018-5177-x