Wiendl, HeinzHeinzWiendlBarkhof, FrederikFrederikBarkhofMontalban, XavierXavierMontalbanAchiron, AnatAnatAchironDerfuss, TobiasTobiasDerfussChan, AndrewAndrewChanHodgkinson, SuzanneSuzanneHodgkinsonPrat, AlexandreAlexandrePratLeocani, LetiziaLetiziaLeocaniSchmierer, KlausKlausSchmiererSellebjerg, FinnFinnSellebjergVermersch, PatrickPatrickVermerschJin, HulinHulinJinChudecka-głaz AnitaKloetgen, AndreasAndreasKloetgenDongdong, LinLinDongdongGardner, LidiaLidiaGardnerDe Nicola Stefano2025-02-042025-02-042025-02-03https://boris-portal.unibe.ch/handle/20.500.12422/204273Cladribine tablets (CladT) represent an effective immune reconstitution therapy, administered in short treatment courses over two consecutive years. To better understand the amplitude of immune changes, we performed a comprehensive analysis during the 2-year study period for the entire MAGNIFY-MS population (N=270). In addition to lymphocyte kinetics, we studied intracellular cytokines serum proteins, and their associations with clinical outcomes. To put these changes into perspective, we analyzed transcriptional changes in T and B cells and associated biological pathways before and after each treatment course with CladT.enarticle10.48620/851273996313410.3389/fimmu.2025.1512189