Guenat, Olivier ThierryOlivier ThierryGuenat0000-0003-1103-9712Zamprogno, Pauline Gil VéroniquePauline Gil VéroniqueZamprogno2024-10-112024-10-112022https://boris-portal.unibe.ch/handle/20.500.12422/85644Standard in vitro models fail to reproduce the complex cellular microenvironment of the human lung, whereas lung animal models poorly predict drug response in humans. A powerful alternative to model various aspects of the air-blood barrier is lung-on-chips using a thin and porous polymeric membrane. Researchers from the University of Bern have developed a new generation lung-on-chip that mimics an array of alveoli based on a biological membrane, on which patient cells are cultured, opening new potentials for lung research, drug screening and personalized medicine.de500 - Science::570 - Life sciences; biology600 - Technology::610 - Medicine & health600 - Technology::620 - Engineeringarticle10.48350/17068910.1007/s12268-022-1731-8