Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study

Mueller, FFMuellerBüchel, BarbaraBarbaraBüchelKöberle, DDKöberleSchürch, StefanStefanSchürchPfister, BBPfisterKrähenbühl, StStKrähenbühlFröhlich, TanjaTanjaFröhlichLargiadèr, Carlo RodolfoCarlo RodolfoLargiadèrJoerger, MMJoerger2024-10-112024-10-112013https://boris-portal.unibe.ch/handle/20.500.12422/84720This study was initiated to assess the quantitative impact of patient anthropometrics and dihydropyrimidine dehydrogenase (DPYD) mutations on the pharmacokinetics (PK) of 5-fluorouracil (5FU) and to explore limited sampling strategies of 5FU.en600 - Technology::610 - Medicine & health500 - Science::570 - Life sciences; biology500 - Science::540 - ChemistryGender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic studyarticle10.48350/146612313905400031404420001010.1007/s00280-012-2018-4