Snyder, Michael PMichael PSnyderGingeras, Thomas RThomas RGingerasMoore, Jill EJill EMooreWeng, ZhipingZhipingWengGerstein, Mark BMark BGersteinRen, BingBingRenHardison, Ross CRoss CHardisonStamatoyannopoulos, John AJohn AStamatoyannopoulosGraveley, Brenton RBrenton RGraveleyFeingold, Elise AElise AFeingoldPazin, Michael JMichael JPazinPagan, MichaelMichaelPaganGilchrist, Daniel ADaniel AGilchristHitz, Benjamin CBenjamin CHitzCherry, J MichaelJ MichaelCherryBernstein, Bradley EBradley EBernsteinMendenhall, Eric MEric MMendenhallZerbino, Daniel RDaniel RZerbinoFrankish, AdamAdamFrankishFlicek, PaulPaulFlicekMyers, Richard MRichard MMyers2024-09-022024-09-022020-07https://boris-portal.unibe.ch/handle/20.500.12422/36943The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.1461083272824810.1038/s41586-020-2449-8