Bousquet, JeanJeanBousquetAnto, Josep MJosep MAntoSterk, Peter JPeter JSterkAdcock, Ian MIan MAdcockChung, Kian FanKian FanChungRoca, JosepJosepRocaAgusti, AlvarAlvarAgustiBrightling, ChrisChrisBrightlingCambon-Thomsen, AnneAnneCambon-ThomsenCesario, AlfredoAlfredoCesarioAbdelhak, SoniaSoniaAbdelhakAntonarakis, Stylianos EStylianos EAntonarakisAvignon, AntoineAntoineAvignonBallabio, AndreaAndreaBallabioBaraldi, EugenioEugenioBaraldiBaranov, AlexanderAlexanderBaranovBieber, ThomasThomasBieberBockaert, JoëlJoëlBockaertBrahmachari, SamirSamirBrahmachariBrambilla, ChristianChristianBrambillaBringer, JacquesJacquesBringerDauzat, MichelMichelDauzatErnberg, IngemarIngemarErnbergFabbri, LeonardoLeonardoFabbriFroguel, PhilippePhilippeFroguelGalas, DavidDavidGalasGojobori, TakashiTakashiGojoboriHunter, PeterPeterHunterJorgensen, ChristianChristianJorgensenKauffmann, FrancineFrancineKauffmannKourilsky, PhilippePhilippeKourilskyKowalski, Marek LMarek LKowalskiLancet, DoronDoronLancetPen, Claude LeClaude LePenMallet, JacquesJacquesMalletMayosi, BonganiBonganiMayosiMercier, JacquesJacquesMercierMetspalu, AndresAndresMetspaluNadeau, Joseph HJoseph HNadeauNinot, GrégoryGrégoryNinotNoble, DenisDenisNobleOztürk, MehmetMehmetOztürkPalkonen, SusannaSusannaPalkonenPréfaut, ChristianChristianPréfautRabe, KlausKlausRabeRenard, EricEricRenardRoberts, Richard GRichard GRobertsSamolinski, BoleslavBoleslavSamolinskiSchünemann, Holger JHolger JSchünemannSimon, Hans-UweHans-UweSimon0000-0002-9404-7736Soares, Marcelo BentoMarcelo BentoSoaresSuperti-Furga, GiulioGiulioSuperti-FurgaTegner, JesperJesperTegnerVerjovski-Almeida, SergioSergioVerjovski-AlmeidaWellstead, PeterPeterWellsteadWolkenhauer, OlafOlafWolkenhauerWouters, EmielEmielWoutersBalling, RudiRudiBallingBrookes, Anthony JAnthony JBrookesCharron, DominiqueDominiqueCharronPison, ChristopheChristophePisonChen, ZhuZhuChenHood, LeroyLeroyHoodAuffray, CharlesCharlesAuffray2024-10-112024-10-112011https://boris-portal.unibe.ch/handle/20.500.12422/76121We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.enarticle10.7892/boris.54992174541700020862740004310.1186/gm259