The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.

Siripanthong, BhurintBhurintSiripanthongAsatryan, BabkenBabkenAsatryan0000-0002-0050-5717Hanff, Thomas CThomas CHanffChatha, Salman RSalman RChathaKhanji, Mohammed YMohammed YKhanjiRicci, FabrizioFabrizioRicciMuser, DanieleDanieleMuserFerrari, Victor AVictor AFerrariNazarian, SamanSamanNazarianSantangeli, PasqualePasqualeSantangeliDeo, RajatRajatDeoCooper, Leslie TLeslie TCooperMohiddin, Saidi ASaidi AMohiddinChahal, C Anwar AC Anwar AChahal2024-10-092024-10-092022-03https://boris-portal.unibe.ch/handle/20.500.12422/67664The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.enCMRcardiovascular magnetic resonance COVID-19 COVID-19coronavirus disease 2019 CTComputerized Tomography LGElate gadolinium enhancement MImyocardial infarction SARS-CoV-2severe acute respiratory syndrome coronavirus-2 athlete cardiovascular magnetic resonance imaging inflammation myocardial injury myocarditis sudden cardiac death troponin600 - Technology::610 - Medicine & healthThe Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.article10.48350/1657993516566510.1016/j.jacbts.2021.10.011