Korten, Insa Christina SeverineInsa Christina SeverineKorten0000-0002-6184-5280Oestreich, Marc-Alexander HeinzMarc-Alexander HeinzOestreich0000-0001-9641-3691Frey, UrsUrsFreyMoeller, AlexanderAlexanderMoellerJung, AndreasAndreasJungSpinas, RenateRenateSpinasMueller-Suter, DominikDominikMueller-SuterTrachsel, DanielDanielTrachselRochat, IsabelleIsabelleRochatSpycher, BenBenSpycher0000-0002-1430-5695Latzin, PhilippPhilippLatzin0000-0002-5239-1571Casaulta, CarmenCarmenCasaulta0000-0003-4754-1608Ramsey, Kathryn AngelaKathryn AngelaRamsey2024-10-052024-10-052021-11https://boris-portal.unibe.ch/handle/20.500.12422/57187BACKGROUND Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known. METHODS We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life. RESULTS We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms. CONCLUSIONS We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.enCohort study Cystic fibrosis Healthy controls Infancy Respiratory symptoms600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1590153408861210.1016/j.jcf.2021.04.006