Radulovic, KatarinaKatarinaRadulovicAyata, C KorcanC KorcanAyataMak'Anyengo, RachelRachelMak'AnyengoLechner, KristinaKristinaLechnerWuggenig, PhilippPhilippWuggenigKaya, BernaBernaKayaHruz, PetrPetrHruzGomez de Agüero Tamargo, Maria de la MercedesMaria de la MercedesGomez de Agüero TamargoBroz, PetrPetrBrozWeigmann, BennoBennoWeigmannNiess, Jan HendrikJan HendrikNiess2024-10-282024-10-282019-07-15https://boris-portal.unibe.ch/handle/20.500.12422/185555The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4+ T cells led to decreased survival.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.1381893115207810.4049/jimmunol.1800938