Pitton, Melissa Phung-KieuMelissa Phung-KieuPittonOberhänsli, SimoneSimoneOberhänsliAppiah, FionaFionaAppiahPagani, Jean-LucJean-LucPaganiFournier, AnneAnneFournierJakob, StephanStephanJakobQue, Yok-AiYok-AiQue0000-0001-9443-6101Cameron, David RobertDavid RobertCameron2024-10-112024-10-112022-07-19https://boris-portal.unibe.ch/handle/20.500.12422/86293Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa.enPseudomonas aeruginosa SCV aminoglycosides antibiotic resistance burn wound infection gentamicin small-colony variant tobramycin600 - Technology::610 - Medicine & healtharticle10.48350/1714803585236410.1128/aac.00621-22