Tüzün, MarinaMarinaTüzünKallweit, UlfUlfKallweitSeidel, StefanStefanSeidelEndrich, OlgaOlgaEndrichTrelle, SvenSvenTrelle0000-0002-8162-8910Leone, Maurizio AMaurizio ALeoneBruni, OlivieroOlivieroBruniDodel, RichardRichardDodelKonti, MariaMariaKontiLolich, MariaMariaLolichPupillo, ElisabettaElisabettaPupilloRamankulov, DaurenDaurenRamankulovVignatelli, LucaLucaVignatelliMeyer-Massetti, Carla VerenaCarla VerenaMeyer-MassettiSchmidt, Markus HelmutMarkus HelmutSchmidtBassetti, Claudio L. A.Claudio L. A.Bassetti2024-11-042024-11-042024-09-06https://boris-portal.unibe.ch/handle/20.500.12422/125316Excessive daytime sleepiness (EDS) and insomnia (IN) complaints represent the most common sleep/wake disorders. Currently, the specific needs of these patients and their relatives, as well as the overall socio-economic burden of IN and EDS remains widely unexplored. This pilot study to be carried out in Switzerland is a retro- and prospective, national, one-center cohort observational study for the systematic evaluation of the burden of EDS and IN and its evolution 12 months after the first assessment. Patient recruitment will be organized through 7-8 primary care providers (primary/general care practitioners and pharmacies). Primary outcomes are the prevalence of EDS/IN in the primary care setting and the association between EDS/IN with health-related quality of life (QOL) as assessed with the established instruments. Secondary outcomes are the association between EDS/IN with the presence of comorbidities, number of injuries/accidents, and number of sick/leave days for the subgroup of working subjects. Calculation of direct per-patient costs will be undertaken to analyze the economic implications of sleep/wake disorders, providing valuable insights into the financial burden experienced by affected individuals within the healthcare system. This research will provide information on the feasibility of such a study and inform on aspects of the QOL most associated with EDS/IN. Based on this pilot project, a European multicenter study on the burden of sleep/wake disorders will be conducted by the European Academy of Neurology.enexcessive daytime sleepinessinsomniaquality of lifesleep/wake disorderssocio-economic burden600 - Technology::610 - Medicine & healtharticle10.48620/759753931137110.3390/mps7050070