Black, Dennis M.Dennis M.BlackReid, Ian R.Ian R.ReidCauley, Jane A.Jane A.CauleyCosman, FeliciaFeliciaCosmanLeung, Ping ChungPing ChungLeungLakatos, PeterPeterLakatosLippuner, KurtKurtLippunerCummings, Steven R.Steven R.CummingsHue, Trisha F.Trisha F.HueMukhopadhyay, AmitavaAmitavaMukhopadhyayTan, MoniqueMoniqueTanAftring, R. PaulR. PaulAftringEastell, RichardRichardEastell2024-10-232024-10-232015-05https://boris-portal.unibe.ch/handle/20.500.12422/129312While bisphosphonates reduce fracture risk over 3 to 5 years, the optimal duration of treatment is uncertain. In a randomized extension study (E1) of the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial (HORIZON-PFT), zoledronic acid (ZOL) 5 mg annually for 6 years showed maintenance of bone mineral density (BMD), decrease in morphometric vertebral fractures, and a modest reduction in bone turnover markers (BTMs) compared with discontinuation after 3 years. To investigate the longer-term efficacy and safety of ZOL, a second extension (E2) was conducted to 9 years in which women on ZOL for 6 years in E1 were randomized to either ZOL (Z9) or placebo (Z6P3) for 3 additional years. In this multicenter, randomized, double-blind study, 190 women were randomized to Z9 (n=95) and Z6P3 (n=95). The primary endpoint was change in total hip BMD at year 9 vs. year 6 in Z9 compared with Z6P3. Other secondary endpoints included fractures, BTMs, and safety. From year 6 to 9, the mean change in total hip BMD was -0.54% in Z9 vs. -1.31% in Z6P3 (difference 0.78%; 95% confidence interval [CI]: -0.37%, 1.93%; p=0.183). BTMs showed small, non-significant increases in those who discontinued after 6 years compared with those who continued for 9 years. The number of fractures was low and did not significantly differ by treatment. While generally safe, there was a small increase in cardiac arrhythmias (combined serious and non-serious) in the Z9 group but no significant imbalance in other safety parameters. The results suggest almost all patients who have received six annual ZOL infusions can stop medication for up to 3 years with apparent maintenance of benefits. This article is protected by copyright. All rights reserved.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.631922554538010.1002/jbmr.2442