Benabdelaziz, ImaneImaneBenabdelazizGómez-Ruiz, SantiagoSantiagoGómez-RuizBenkhaled, MohammedMohammedBenkhaledCarralero, SandraSandraCarraleroSchenker, PatriciaPatriciaSchenkerSalm, Andrea AlejandraAndrea AlejandraSalm0000-0003-4326-9264Gertsch, JürgJürgGertschHaba, HamadaHamadaHaba2024-10-082024-10-082018-06https://boris-portal.unibe.ch/handle/20.500.12422/63141From acetonic extract of the whole plant Euphorbia pterococca Brot. (Euphorbiaceae), four new cycloartane-type ester triterpenes named cycloartenyl-2'E,4'E-decadienoate (1), cycloartenyl-2'E,4'Z-decadienoate (2), 24-methylenecycloartanyl-2'E,4'Z-tetradecadienoate (3), and 24-oxo-29-norcycloartanyl-2'E,4'Z-hexadecadienoate (4) were obtained along with nine known tetracyclic triterpenes (5-13). Their structures were established mainly by extensive use of spectroscopic techniques, including 1D (H and C) and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY), and mass spectrometry (HRESIMS), and by comparison with data reported in the literature. In addition, the new compounds 1-3 have been tested for cytotoxicity, trypanocidal effects and on enzymes involved in endocannabinoid degradation. While inactive in all assays up to 100 μM, 1 showed selective inhibition of α/β-hydrolase 12 with an IC of 11.6 ± 1.9 μM.enAlpha/beta hydrolase-12 Cycloartanes Euphorbia pterococca Euphorbiaceae NMR Triterpenoids500 - Science::570 - Life sciences; biology600 - Technology::610 - Medicine & healtharticle10.7892/boris.1250322952456410.1016/j.fitote.2018.02.027