Munk, Marion R.Marion R.MunkStillenmunkes, RichardRichardStillenmunkesTillmann, AnneAnneTillmannJampol, Lee MLee MJampolCicinelli, Maria VittoriaMaria VittoriaCicinelliLin, PhoebePhoebeLinPepple, Kathryn LKathryn LPeppleFreund, K BaileyK BaileyFreundTugal-Tutkun, IlknurIlknurTugal-TutkunHabot-Wilner, ZoharZoharHabot-WilnerAgarwal, AniruddhaAniruddhaAgarwalGangaputra, SapnaSapnaGangaputraAgrawal, RupeshRupeshAgrawalJabs, Douglas ADouglas AJabsSadda, SriniVasSriniVasSaddaSarraf, DavidDavidSarrafGupta, VishaliVishaliGupta2025-06-302025-06-302025-10https://boris-portal.unibe.ch/handle/20.500.12422/212590Purpose To develop imaging and consensus-based guidelines on the application of multimodal imaging in multiple evanescent white dot syndrome (MEWDS). Design Consensus agreement guided by literature, and an expert committee using a nominal group technique (NGT). Methods The expert committee employed a structured NGT with multiple rounds of discussion, conflict resolution, and anonymous voting to: (1) establish imaging criteria for diagnosing and monitoring MEWDS using color fundus photography (CFP), optical coherence tomography (OCT), fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and OCT angiography (OCTA); and (2) develop consensus-based recommendations for assessing specific characteristics in patients with MEWDS. These formal recommendations were derived from a structured NGT using illustrative cases of MEWDS and were further voted upon by the entire task force. Results The diagnosis of acute MEWDS is supported by distinct multimodal features on CFP, multi-focal disruption of the ellipsoid/interdigitation zone with overlying outer retinal hyper-reflectivity with OCT, and hyper-autofluorescent spots with FAF (short-wave blue/green). In complex cases, wreath-like lesions on FFA and the absence of early hypofluorescence on ICGA help differentiate MEWDS from other chorioretinopathies. The lack of specific choroidal changes on OCT and preserved signal on OCTA on retinal and inner choroidal slabs also aid in diagnosis. Conclusions Multimodal imaging is essential for diagnosing MEWDS and differentiating it from other non-infectious uveitis types, extending the Standardization of Uveitis Nomenclature (SUN) classification. These imaging criteria enable detailed assessment of disease activity and offer valuable insights into MEWDS pathogenesis.enMEWDSMultiple evanescent white dot syndromeactivitychoroiditisposterior uveitissecondary MEWDS600 - Technology::610 - Medicine & healtharticle10.48620/888794057104610.1016/j.ajo.2025.06.039