Young, William JWilliam JYoungHaessler, JeffreyJeffreyHaesslerBenjamins, Jan-WalterJan-WalterBenjaminsRepetto, LindaLindaRepettoYao, JieJieYaoIsaacs, AaronAaronIsaacsHarper, Andrew RAndrew RHarperRamirez, JuliaJuliaRamirezGarnier, SophieSophieGarniervan Duijvenboden, StefanStefanvan DuijvenbodenBaldassari, Antoine RAntoine RBaldassariConcas, Maria PinaMaria PinaConcasDuong, ThuyVyThuyVyDuongFoco, LuisaLuisaFocoIsaksen, Jonas LJonas LIsaksenMei, HaoHaoMeiNoordam, RaymondRaymondNoordamNursyifa, CasiaCasiaNursyifaRichmond, AnneAnneRichmondSantolalla, Meddly LMeddly LSantolallaSitlani, Colleen MColleen MSitlaniSoroush, NeginNeginSoroushThériault, SébastienSébastienThériaultTrompet, StellaStellaTrompetAeschbacher, StefanieStefanieAeschbacherAhmadizar, FaribaFaribaAhmadizarAlonso, AlvaroAlvaroAlonsoBrody, Jennifer AJennifer ABrodyCampbell, ArchieArchieCampbellCorrea, AdolfoAdolfoCorreaDarbar, DawoodDawoodDarbarDe Luca, AntonioAntonioDe LucaDeleuze, Jean-FrançoisJean-FrançoisDeleuzeEllervik, ChristinaChristinaEllervikFuchsberger, ChristianChristianFuchsbergerGoel, AnujAnujGoelGrace, ChristopherChristopherGraceGuo, XiuqingXiuqingGuoHansen, TorbenTorbenHansenHeckbert, Susan RSusan RHeckbertJackson, Rebecca DRebecca DJacksonKors, Jan AJan AKorsLima-Costa, Maria FernandaMaria FernandaLima-CostaLinneberg, AllanAllanLinnebergMacfarlane, Peter WPeter WMacfarlaneMorrison, Alanna CAlanna CMorrisonNavarro, PauPauNavarroPorteous, David JDavid JPorteousPramstaller, Peter PPeter PPramstallerReiner, Alexander PAlexander PReinerRisch, LorenzLorenzRisch0000-0003-2692-6699Schotten, UlrichUlrichSchottenShen, XiaXiaShenSinagra, GianfrancoGianfrancoSinagraSoliman, Elsayed ZElsayed ZSolimanStoll, MonikaMonikaStollTarazona-Santos, EduardoEduardoTarazona-SantosTinker, AndrewAndrewTinkerTrajanoska, KaterinaKaterinaTrajanoskaVillard, EricEricVillardWarren, Helen RHelen RWarrenWhitsel, Eric AEric AWhitselWiggins, Kerri LKerri LWigginsArking, Dan EDan EArkingAvery, Christy LChristy LAveryConen, DavidDavidConenGirotto, GiorgiaGiorgiaGirottoGrarup, NielsNielsGrarupHayward, CarolineCarolineHaywardJukema, J WouterJ WouterJukemaMook-Kanamori, Dennis ODennis OMook-KanamoriOlesen, Morten SallingMorten SallingOlesenPadmanabhan, SandoshSandoshPadmanabhanPsaty, Bruce MBruce MPsatyPattaro, CristianCristianPattaroRibeiro, Antonio Luiz PAntonio Luiz PRibeiroRotter, Jerome IJerome IRotterStricker, Bruno HBruno HStrickervan der Harst, PimPimvan der Harstvan Duijn, Cornelia MCornelia Mvan DuijnVerweij, NiekNiekVerweijWilson, James GJames GWilsonOrini, MicheleMicheleOriniCharron, PhilippePhilippeCharronWatkins, HughHughWatkinsKooperberg, CharlesCharlesKooperbergLin, Henry JHenry JLinWilson, James FJames FWilsonKanters, Jørgen KJørgen KKantersSotoodehnia, NonaNonaSotoodehniaMifsud, BorbalaBorbalaMifsudLambiase, Pier DPier DLambiaseTereshchenko, Larisa GLarisa GTereshchenkoMunroe, Patricia BPatricia BMunroe2024-10-252024-10-252023-03-14https://boris-portal.unibe.ch/handle/20.500.12422/165247The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.en600 - Technology::610 - Medicine & healtharticle10.48350/1801943691854110.1038/s41467-023-36997-w