Frederiksen, Ida NIda NFrederiksenMuttuvelu, Danson VDanson VMuttuveluAnguita, RodrigoRodrigoAnguitaCehofski, Lasse JLasse JCehofskiEriksen, Nathalie SNathalie SEriksenFaber, CarstenCarstenFaberFalk, Mads KMads KFalkFerro Desideri, LorenzoLorenzoFerro Desideri0000-0003-0715-6369Giannaccare, GiuseppeGiuseppeGiannaccareGrauslund, JakobJakobGrauslundHansen, Michael StormlyMichael StormlyHansenHuemer, JosefJosefHuemerLarsen, Morten BMorten BLarsenKiruparajan, Ligor PLigor PKiruparajanSøndergaard, Chris BChris BSøndergaardTaloni, AndreaAndreaTaloniTorp-Pedersen, Tobias ETobias ETorp-Pedersenvan Dijk, Elon H CElon H Cvan DijkRasmussen, Marie L RMarie L RRasmussenSubhi, YousifYousifSubhi2025-05-262025-05-262025-05-11https://boris-portal.unibe.ch/handle/20.500.12422/211220Purpose Central serous chorioretinopathy (CSC) is a prevalent maculopathy, but epidemiological studies are few. In this study, we determined the prevalence of CSC for the first time in a Scandinavian population.Methods This cross-sectional study was based on nationwide opportunistic retinal examination from 79 high street chain optician stores in Denmark. Retinal imaging was made using non-mydriatic colour fundus photography. Any abnormal result in the optometrist-facilitated retinal examination was referred to tele-ophthalmologic evaluation, which was performed by experienced consultant ophthalmologists who diagnosed CSC.Results During the 4-year study period, a total of 968 610 unique individuals underwent retinal examination, which corresponded to 16.3% of the entire population of Denmark. Of these, 113 individuals were diagnosed with CSC, which corresponded to a prevalence of 14 per 100 000. Individuals with CSC presented at a mean age of 48.2 ± 12.3 years; however, CSC was present in a large age range as both teenagers and the elderly with CSC were identified. Male biological sex was a statistically significant risk factor (odds ratio: 2.33; 95% confidence interval: 1.64-3.33, p < 0.0001). By extrapolating prevalence numbers to population statistics, we estimate that 219 females and 511 males had CSC in Denmark in December 2022.Conclusion We identified a prevalence of 14 per 100 000, confirmed male biological sex as a significant risk factor for CSC, and found that the disease most commonly occurs among individuals aged 30-60 years. Further studies with multimodal imaging including optical coherence tomography are warranted for better accuracy.enDenmarkcentral serous chorioretinopathyepidemiologyprevalence600 - Technology::610 - Medicine & healtharticle10.48620/882334035096710.1111/aos.17520