Zaniewski, ElizabethElizabethZaniewskiWhitesell Skrivankova, VeronikaVeronikaWhitesell Skrivankova0000-0003-0932-4792Brazier, EllenEllenBrazierAvihingsanon, AnchaleeAnchaleeAvihingsanonCardoso, Sandra WagnerSandra WagnerCardosoCesar, CarinaCarinaCesarChenal, HenriHenriChenalCrabtree-Ramírez, Brenda EBrenda ECrabtree-RamírezDitangco, Rossana ARossana ADitangcoEbasone, Peter VanesPeter VanesEbasoneEley, BrianBrianEleyEuvrard, Jonathan GeorgeJonathan GeorgeEuvrardFatti, GeoffreyGeoffreyFattiHuwa, Jacqueline MadalitsoJacqueline MadalitsoHuwaLelo, PatriciaPatriciaLeloMachado, Daisy MariaDaisy MariaMachadoMessou, Eugene KouassiEugene KouassiMessouMinga, Albert KlaAlbert KlaMingaMuleebwa, JosephJosephMuleebwaMundhe, SanjaySanjayMundheMurenzi, GadGadMurenziMuyindike, Winnie RWinnie RMuyindikeNsonde, Dominique MahambouDominique MahambouNsondeObatsa, Sarah MSarah MObatsaOdhiambo, JosephJosephOdhiamboProzesky, Hans WalterHans WalterProzeskyRungmaitree, SupattraSupattraRungmaitreeSemeere, Aggrey SemwenderoAggrey SemwenderoSemeereSeydi, MoussaMoussaSeydiSipambo, NosisaNosisaSipamboSudjaritruk, TavitiyaTavitiyaSudjaritrukTechnau, Karl-GünterKarl-GünterTechnauTiendrebeogo, ThierryThierryTiendrebeogoTwizere, ChristelleChristelleTwizereBallif, MarieMarieBallif0000-0003-3133-30112024-10-222024-10-222024-09-05https://boris-portal.unibe.ch/handle/20.500.12422/47905Objective We studied the transition to dolutegravir-containing antiretroviral therapy (ART) at HIV treatment clinics within the International epidemiology Databases to Evaluate AIDS (IeDEA). Design Site-level survey conducted in 2020-2021 among HIV clinics in low- and middle-income countries (LMICs). Methods We assessed the status of dolutegravir rollout and viral load and drug resistance testing practices for patients on ART switching to dolutegravir-based regimens. We used generalized estimating equations to assess associations between clinic rollout of both first- and second-line dolutegravir-based ART regimens (dual rollout) and site-level factors. Results Of 179 surveyed clinics, 175 (98%) participated; 137 (78%) from Africa, 30 (17%) from the Asia-Pacific, and 8 (5%) from Latin America. Most clinics (80%) were in low- or lower-middle-income countries, and there were a mix of primary-, secondary- and tertiary-level clinics. Ninety percent reported rollout of first-line dolutegravir, 59% of second-line, 94% of first- or second-line and 55% of dual rollout. The adjusted odds of dual rollout were higher among tertiary-level (aOR 4.00; 95% CI 1.39 to 11.47) and secondary-level clinics (aOR 3.66; 95% CI 2.19 to 6.11) than in primary-level clinics. Over half (59%) of clinics that introduced first- or second-line dolutegravir-based ART required recent viral load testing before switching to dolutegravir, and 15% performed genotypic resistance testing at switch. Conclusions Dolutegravir-based ART was rolled out at nearly all IeDEA clinics in LMICs, yet many switched patients to dolutegravir without recent viral load testing and drug resistance testing was rarely performed. Without such testing, drug resistance among patient switching to dolutegravir may go undetected.en600 - Technology::610 - Medicine & healtharticle10.48620/364373923611210.1097/QAD.0000000000004007