Berberich, AnneAnneBerberichHerweh, ChristianChristianHerwehQureshi, Muhammad MMuhammad MQureshiStrambo, DavideDavideStramboMichel, PatrikPatrikMichelRäty, SiljaSiljaRätyAbdalkader, MohamadMohamadAbdalkaderVirtanen, PekkaPekkaVirtanenOlive Gadea, MartaMartaOlive GadeaRibo, MarcMarcRiboPsychogios, Marios-NikosMarios-NikosPsychogiosNguyen, AnhAnhNguyenKuramatsu, Joji BJoji BKuramatsuHaupenthal, DavidDavidHaupenthalKöhrmann, MartinMartinKöhrmannDeuschl, CorneliusCorneliusDeuschlKühne Escolà, JordiJordiKühne EscolàDemeestere, JelleJelleDemeestereLemmens, RobinRobinLemmensYaghi, ShadiShadiYaghiShu, LiqiLiqiShuKaiser, Daniel P ODaniel P OKaiserPuetz, VolkerVolkerPuetzKaesmacher, JohannesJohannesKaesmacherMujanović, AdnanAdnanMujanovićMarterstock, Dominique CorneliusDominique CorneliusMarterstockEngelhorn, TobiasTobiasEngelhornKlein, PiersPiersKleinHaussen, Diogo CDiogo CHaussenMohammaden, Mahmoud HMahmoud HMohammadenCunha, BrunoBrunoCunhaFragata, IsabelIsabelFragataRomoli, MicheleMicheleRomoliHu, WeiWeiHuZhang, ChaoChaoZhangMatsoukas, StavrosStavrosMatsoukasFifi, Johanna TJohanna TFifiSheth, Sunil ASunil AShethSalazar-Marioni, SergioSergioSalazar-MarioniMarto, JoaoJoaoMartoRamos, João NunoJoão NunoRamosMiszczuk, MilenaMilenaMiszczukRiegler, ChristophChristophRieglerPoli, SvenSvenPoliPoli, KhouloudKhouloudPoliJadhav, Ashutosh PAshutosh PJadhavDesai, Shashvat MShashvat MDesaiMaus, VolkerVolkerMausKaeder, MaximilianMaximilianKaederSiddiqui, Adnan HAdnan HSiddiquiMonteiro, AndreAndreMonteiroPeltola, ErnoErnoPeltolaMasoud, HeshamHeshamMasoudSuryadareva, NeilNeilSuryadarevaMokin, MaximMaximMokinThanki, ShailShailThankiAlpay, KemalKemalAlpayRautio, RiittaRiittaRautioSiegler, James EJames ESieglerAsdaghi, NegarNegarAsdaghiSaini, VasuVasuSainiLinfante, ItaloItaloLinfanteDabus, GuilhermeGuilhermeDabusNolte, Christian HChristian HNolteSiebert, EberhardEberhardSiebertMöhlenbruch, Markus AMarkus AMöhlenbruchFischer, Urs MartinUrs MartinFischerNogueira, Raul GRaul GNogueiraHanning, UtaUtaHanningMeyer, LukasLukasMeyerRingleb, Peter ArthurPeter ArthurRinglebStrbian, DanielDanielStrbianNguyen, Thanh NThanh NNguyenNagel, SimonSimonNagel2024-10-262024-10-262024-06https://boris-portal.unibe.ch/handle/20.500.12422/177987BACKGROUND The optimal anesthetic strategy for endovascular therapy (EVT) in acute ischemic stroke is still under debate. The aim of this study was to compare the clinical outcomes of patients with isolated posterior cerebral artery (PCA) occlusion stroke undergoing EVT by anesthesia modality with conscious sedation (non-GA) versus general anesthesia (GA). METHODS Patients from the Posterior CerebraL Artery Occlusion (PLATO) study were analyzed with regard to anesthetic strategy. GA was compared with non-GA using multivariable logistic regression and inverse probability of weighting treatment (IPTW) methods. The primary endpoint was the 90-day distribution of the modified Rankin Scale (mRS) score. Secondary outcomes included functional independence or return to Rankin at day 90, and successful reperfusion, defined as expanded Thrombolysis in Cerebral Infarction (eTICI) 2b to 3. Safety endpoints were symptomatic intracranial hemorrhage and mortality. RESULTS Among 376 patients with isolated PCA occlusion stroke treated with EVT, 183 (49%) had GA. The treatment groups were comparable, although the GA group contained more patients with severe stroke and lower posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS). On IPTW analysis, there was no difference between groups with regard to ordinal mRS shift analysis (common OR 0.89, 95% CI 0.53 to 1.51, P=0.67) or functional independence (OR 0.84, 95% CI 0.50 to 1.39, P=0.49). There were greater odds for successful reperfusion with GA (OR 1.70, 95% CI 1.17 to 2.47, P=0.01). Safety outcomes were comparable between groups. CONCLUSION In patients with isolated PCA occlusion undergoing EVT, patients treated with GA had higher reperfusion rates compared with non-GA. Both GA and non-GA strategies were safe and functional outcomes were similar.enIntervention Stroke Thrombectomy600 - Technology::610 - Medicine & healtharticle10.48350/1976103883928210.1136/jnis-2024-021633