Fernández Regueiro, Cristina LíaCristina LíaFernández RegueiroRoura Padrosa, DavidDavidRoura PadrosaParadisi, FrancescaFrancescaParadisi0000-0003-1704-06422025-04-082025-04-082025https://boris-portal.unibe.ch/handle/20.500.12422/209340Biocatalysis and flow chemistry are two complementary technologies that can be used to produce chemicals in a more efficient, sustainable, and safe manner. Enzyme immobilization is key to enabling their combination. Various immobilization methods, including carrier-free and carrier- based techniques, offer distinct advantages in terms of enzyme activity, stability, and productivity. This review explores these immobilization strategies and their integration in packed-bed reactors, highlighting their industrial applications and potential challenges.enarticle10.48620/8710110.5802/crchim.386