Roccio, MartaMartaRoccioEdge, Albert S. B.Albert S. B.Edge2024-10-282024-10-282019-09-02https://boris-portal.unibe.ch/handle/20.500.12422/185513The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.enHair cells Inner ear Organoids Regeneration Stem cells600 - Technology::610 - Medicine & healtharticle10.7892/boris.1381383147758010.1242/dev.177188