Schmidt, Dr. WernerDr. WernerSchmidtSchulze, Dr. T.M.Dr. T.M.SchulzeBrasse, Dr. G.Dr. G.BrasseNagrodzka, Dr. E.Dr. E.NagrodzkaMaczka, M.M.MaczkaGrunenberg, Prof. Dr. J.Prof. Dr. J.GrunenbergSchulz, Prof. Dr. S.Prof. Dr. S.SchulzJones, Prof. Dr. P. G.Prof. Dr. P. G.JonesZettel, JürgJürgZettelHilker, Prof. Dr. M.Prof. Dr. M.Hilker2024-10-242024-10-242015https://boris-portal.unibe.ch/handle/20.500.12422/145396The snow flea Ceratophysella sigillata, a winter-active species of springtail, produces unique polychlorinated octahydroisocoumarins to repel predators. The structure of the major compound, sigillin A, was elucidated through isolation, spectroscopic analysis, and X-ray crystallography. Sigillin A showed high repellent activity in a bioassay with predatory ants. A promising approach for the total synthesis of members of this new class of natural compounds was also developed.enarticle10.7892/boris.8881310.1002/anie.201501719