Chen, XinXinChenTsvetkov, Andrey SAndrey STsvetkovShen, Han-MingHan-MingShenIsidoro, CiroCiroIsidoroKtistakis, Nicholas TNicholas TKtistakisLinkermann, AndreasAndreasLinkermannKoopman, Werner J HWerner J HKoopmanSimon, Hans-UweHans-UweSimon0000-0002-9404-7736Galluzzi, LorenzoLorenzoGalluzziLuo, ShouqingShouqingLuoXu, DaqianDaqianXuGu, WeiWeiGuPeulen, OlivierOlivierPeulenCai, QianQianCaiRubinsztein, David CDavid CRubinszteinChi, Jen-TsanJen-TsanChiZhang, Donna DDonna DZhangLi, ChangfengChangfengLiToyokuni, ShinyaShinyaToyokuniLiu, JinbaoJinbaoLiuRoh, Jong-LyelJong-LyelRohDai, EnyongEnyongDaiJuhasz, GaborGaborJuhaszLiu, WeiWeiLiuZhang, JianhuaJianhuaZhangYang, MinghuaMinghuaYangLiu, JiaoJiaoLiuZhu, Ling-QiangLing-QiangZhuZou, WeipingWeipingZouPiacentini, MauroMauroPiacentiniDing, Wen-XingWen-XingDingYue, ZhenyuZhenyuYueXie, YangchunYangchunXiePetersen, MortenMortenPetersenGewirtz, David ADavid AGewirtzMandell, Michael AMichael AMandellChu, Charleen TCharleen TChuSinha, DebasishDebasishSinhaEftekharpour, EftekharEftekharEftekharpourZhivotovsky, BorisBorisZhivotovskyBesteiro, SébastienSébastienBesteiroGabrilovich, Dmitry IDmitry IGabrilovichKim, Do-HyungDo-HyungKimKagan, Valerian EValerian EKaganBayir, HülyaHülyaBayirChen, Guang-ChaoGuang-ChaoChenAyton, ScottScottAytonLünemann, Jan DJan DLünemannKomatsu, MasaakiMasaakiKomatsuKrautwald, StefanStefanKrautwaldLoos, BenBenLoosBaehrecke, Eric HEric HBaehreckeWang, JiayiJiayiWangLane, Jon DJon DLaneSadoshima, JunichiJunichiSadoshimaYang, Wan SeokWan SeokYangGao, MinghuiMinghuiGaoMünz, ChristianChristianMünzThumm, MichaelMichaelThummKampmann, MartinMartinKampmannYu, DiDiYuLipinski, Marta MMarta MLipinskiJones, Jace WJace WJonesJiang, XuejunXuejunJiangZeh, Herbert JHerbert JZehKang, RuiRuiKangKlionsky, Daniel JDaniel JKlionskyKroemer, GuidoGuidoKroemerTang, DaolinDaolinTang2024-10-262024-10-262024-06https://boris-portal.unibe.ch/handle/20.500.12422/175231Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.enCell death ferritinophagy iron lipid peroxidation lipophagy lysosome600 - Technology::610 - Medicine & healtharticle10.48350/1938873844289010.1080/15548627.2024.2319901