Häberli, A.A.HäberliLeumann, ChristianChristianLeumann0000-0002-7996-70832024-10-232024-10-232001https://boris-portal.unibe.ch/handle/20.500.12422/133084A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be converted to the corresponding phosphoramidite building blocks for DNA synthesisenBUILDING-BLOCKS C-nucleosides DNA phosphoramidite pyrrolidino-DNA synthesis500 - Science::570 - Life sciences; biology500 - Science::540 - Chemistryarticle10.7892/boris.6859010.1021/ol007029s