Yadlapati, RenaRenaYadlapatiKahrilas, Peter JPeter JKahrilasFox, Mark RMark RFoxBredenoord, Albert JAlbert JBredenoordPrakash Gyawali, CCPrakash GyawaliRoman, SabineSabineRomanBabaei, ArashArashBabaeiMittal, Ravinder KRavinder KMittalRommel, NathalieNathalieRommelSavarino, EdoardoEdoardoSavarinoSifrim, DanielDanielSifrimSmout, AndréAndréSmoutVaezi, Michael FMichael FVaeziZerbib, FrankFrankZerbibAkiyama, JunichiJunichiAkiyamaBhatia, ShobnaShobnaBhatiaBor, SerhatSerhatBorCarlson, Dustin ADustin ACarlsonChen, Joan WJoan WChenCisternas, DanielDanielCisternasCock, CharlesCharlesCockCoss-Adame, EnriqueEnriqueCoss-Adamede Bortoli, NicolaNicolade BortoliDefilippi, ClaudiaClaudiaDefilippiFass, RonnieRonnieFassGhoshal, Uday CUday CGhoshalGonlachanvit, SutepSutepGonlachanvitHani, AlbisAlbisHaniHebbard, Geoffrey SGeoffrey SHebbardWook Jung, KeeKeeWook JungKatz, PhilipPhilipKatzKatzka, David ADavid AKatzkaKhan, AbrahamAbrahamKhanKohn, Geoffrey PaulGeoffrey PaulKohnLazarescu, AdrianaAdrianaLazarescuLenglinger, JohannesJohannesLenglingerMittal, Sumeet KSumeet KMittalOmari, TaherTaherOmariPark, Moo InMoo InParkPenagini, RobertoRobertoPenaginiPohl, DanielDanielPohlRichter, Joel EJoel ERichterSerra, JordiJordiSerraSweis, RamiRamiSweisTack, JanJanTackTatum, Roger PRoger PTatumTutuian, RaduRaduTutuianVela, Marcelo FMarcelo FVelaWong, Reuben KReuben KWongWu, Justin CJustin CWuXiao, YinglianYinglianXiaoPandolfino, John EJohn EPandolfino2024-10-092024-10-092021-01https://boris-portal.unibe.ch/handle/20.500.12422/66649Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high-resolution manometry (HRM). Fifty-two diverse international experts separated into seven working subgroups utilized formal validated methodologies over two-years to develop CCv4.0. Key updates in CCv.4.0 consist of a more rigorous and expansive HRM protocol that incorporates supine and upright test positions as well as provocative testing, a refined definition of esophagogastric junction (EGJ) outflow obstruction (EGJOO), more stringent diagnostic criteria for ineffective esophageal motility and description of baseline EGJ metrics. Further, the CCv4.0 sought to define motility disorder diagnoses as conclusive and inconclusive based on associated symptoms, and findings on provocative testing as well as supportive testing with barium esophagram with tablet and/or functional lumen imaging probe. These changes attempt to minimize ambiguity in prior iterations of Chicago Classification and provide more standardized and rigorous criteria for patterns of disorders of peristalsis and obstruction at the EGJ.enachalasia esophageal spasm integrated relaxation pressure lower esophageal sphincter peroral endoscopic myotomy600 - Technology::610 - Medicine & healtharticle10.48350/1643603337311110.1111/nmo.14058