Marto, João PedroJoão PedroMartoStrambo, DavideDavideStramboNtaios, GeorgeGeorgeNtaiosNguyen, Thanh NThanh NNguyenHerzig, RomanRomanHerzigCzlonkowska, AnnaAnnaCzlonkowskaDemeestere, JelleJelleDemeestereMansour, Ossama YassinOssama YassinMansourSalerno, AlexanderAlexanderSalernoWegener, SusanneSusanneWegenerBaumgartner, PhilippPhilippBaumgartnerCereda, Carlo WCarlo WCeredaBianco, GiovanniGiovanniBiancoBeyeler, MorinMorinBeyelerArnold, MarcelMarcelArnoldCarrera, EmmanuelEmmanuelCarreraMachi, PaoloPaoloMachiAltersberger, ValerianValerianAltersbergerBonati, LeoLeoBonatiGensicke, HenrikHenrikGensickeBolognese, ManuelManuelBolognesePeters, NilsNilsPetersWetzel, StephanStephanWetzelMagriço, MartaMartaMagriçoRamos, João NunoJoão NunoRamosSargento-Freitas, JoãoJoãoSargento-FreitasMachado, RitaRitaMachadoMaia, CarolinaCarolinaMaiaMachado, EgídioEgídioMachadoNunes, Ana PaivaAna PaivaNunesFerreira, PatriciaPatriciaFerreiraPinho E Melo, TeresaTeresaPinho E MeloDias, Mariana CarvalhoMariana CarvalhoDiasPaula, AndréAndréPaulaCorreia, Manuel AlbertoManuel AlbertoCorreiaCastro, PedroPedroCastroAzevedo, ElsaElsaAzevedoAlbuquerque, LuísLuísAlbuquerqueAlves, José NunoJosé NunoAlvesFerreira-Pinto, JoanaJoanaFerreira-PintoMeira, TorcatoTorcatoMeiraPereira, LilianaLilianaPereiraRodrigues, MiguelMiguelRodriguesAraujo, Andre PinhoAndre PinhoAraujoRodrigues, MartaMartaRodriguesRocha, MarianaMarianaRochaPereira-Fonseca, ÂngeloÂngeloPereira-FonsecaRibeiro, LuísLuísRibeiroVarela, RicardoRicardoVarelaMalheiro, SofiaSofiaMalheiroCappellari, ManuelManuelCappellariZivelonghi, CeciliaCeciliaZivelonghiSajeva, GiuliaGiuliaSajevaZini, AndreaAndreaZiniGentile, MauroMauroGentileForlivesi, StefanoStefanoForlivesiMigliaccio, LudovicaLudovicaMigliaccioSessa, MariaMariaSessaLa Gioia, SaraSaraLa GioiaPezzini, AlessandroAlessandroPezziniSangalli, DavideDavideSangalliZedde, MarialuisaMarialuisaZeddePascarella, RosarioRosarioPascarellaFerrarese, CarloCarloFerrareseBeretta, SimoneSimoneBerettaDiamanti, SusannaSusannaDiamantiSchwarz, GhilGhilSchwarzFrisullo, GiovanniGiovanniFrisulloMarcheselli, SimonaSimonaMarcheselliSeners, PierrePierreSenersSabben, CandiceCandiceSabbenEscalard, SimonSimonEscalardPiotin, MichelMichelPiotinMaïer, BenjaminBenjaminMaïerCharbonnier, GuillaumeGuillaumeCharbonnierVuillier, FabriceFabriceVuillierLegris, LoïcLoïcLegrisCuisenier, PaulinePaulineCuisenierVodret, Francesca RFrancesca RVodretMarnat, GaultierGaultierMarnatLiegey, Jean-SebastienJean-SebastienLiegeySibon, IgorIgorSibonFlottmann, FabianFabianFlottmannBroocks, GabrielGabrielBroocksGloyer, Nils-OleNils-OleGloyerBohmann, Ferdinand OFerdinand OBohmannSchaefer, Jan HendrikJan HendrikSchaeferNolte, ChristianChristianNolteAudebert, Heinrich JHeinrich JAudebertSiebert, EberhardEberhardSiebertSykora, MarekMarekSykoraLang, WilfriedWilfriedLangFerrari, JuliaJuliaFerrariMayer-Suess, LukasLukasMayer-SuessKnoflach, MichaelMichaelKnoflachGizewski, Elke RuthElke RuthGizewskiStolp, JeffreyJeffreyStolpStolze, Lotte JLotte JStolzeCoutinho, Jonathan MJonathan MCoutinhoNederkoorn, PaulPaulNederkoornvan den Wijngaard, IdoIdovan den WijngaardDe Meris, JokeJokeDe MerisLemmens, RobinRobinLemmensDe Raedt, SylvieSylvieDe RaedtVandervorst, FenneFenneVandervorstRutgers, Matthieu PierreMatthieu PierreRutgersGuilmot, AntoineAntoineGuilmotDusart, AnneAnneDusartBellante, FlavioFlavioBellanteCalleja-Castaño, PatriciaPatriciaCalleja-CastañoOstos, FernandoFernandoOstosGonzález-Ortega, GuillermoGuillermoGonzález-OrtegaMartín-Jiménez, PalomaPalomaMartín-JiménezGarcía-Madrona, SebastianSebastianGarcía-MadronaCruz-Culebras, AntonioAntonioCruz-CulebrasVera, RocioRocioVeraMatute, Maria ConsueloMaria ConsueloMatuteFuentes, BlancaBlancaFuentesAlonso-de-Leciñana, MaríaMaríaAlonso-de-LeciñanaRigual, RicardoRicardoRigualDíez-Tejedor, ExuperioExuperioDíez-TejedorPerez-Sanchez, SoledadSoledadPerez-SanchezMontaner, JoanJoanMontanerDíaz-Otero, FernandoFernandoDíaz-OteroPérez-de-la-Ossa, NataliaNataliaPérez-de-la-OssaFlores-Pina, BelénBelénFlores-PinaMuñoz-Narbona, LuciaLuciaMuñoz-NarbonaChamorro, AngelAngelChamorroRodríguez-Vázquez, AlejandroAlejandroRodríguez-VázquezRenú, ArturoArturoRenúAyo-Martin, OscarOscarAyo-MartinHernández-Fernández, FranciscoFranciscoHernández-FernándezSegura, TomasTomasSeguraTejada-Meza, HerbertHerbertTejada-MezaSagarra-Mur, DanielDanielSagarra-MurSerrano-Ponz, MartaMartaSerrano-PonzHlaing, ThantThantHlaingSee, IsaiahIsaiahSeeSimister, RobertRobertSimisterWerring, DavidDavidWerringKristoffersen, Espen SaxhaugEspen SaxhaugKristoffersenNordanstig, AnnikaAnnikaNordanstigJood, KatarinaKatarinaJoodRentzos, AlexandrosAlexandrosRentzosŠimůnek, LiborLiborŠimůnekKrajíčková, DagmarDagmarKrajíčkováKrajina, AntonínAntonínKrajinaMikulik, RobertRobertMikulikCviková, MartinaMartinaCvikováVinklárek, JanJanVinklárekŠkoloudík, DavidDavidŠkoloudíkRoubec, MartinMartinRoubecHurtikova, EvaEvaHurtikovaHrubý, RostislavRostislavHrubýOstry, SvatoplukSvatoplukOstrySkoda, OndrejOndrejSkodaPernicka, MarekMarekPernickaJurak, LubomirLubomirJurakEichlová, ZuzanaZuzanaEichlováJíra, MartinMartinJíraKovar, MartinMartinKovarPanský, MichalMichalPanskýMencl, PavelPavelMenclPalouskova, HanaHanaPalouskovaTomek, AlešAlešTomekJanský, PetrPetrJanskýOlšerová, AnnaAnnaOlšerováSramek, MartinMartinSramekHavlicek, RomanRomanHavlicekMalý, PetrPetrMalýTrakal, LukášLukášTrakalFiksa, JanJanFiksaSlovák, MatějMatějSlovákKarlinski, Michal AdamMichal AdamKarlinskiNowak, MaciejMaciejNowakSienkiewicz-Jarosz, HalinaHalinaSienkiewicz-JaroszBochynska, AnnaAnnaBochynskaWrona, PawelPawelWronaHoma, TomaszTomaszHomaSawczynska, KatarzynaKatarzynaSawczynskaSlowik, AgnieszkaAgnieszkaSlowikWlodarczyk, EwaEwaWlodarczykWiacek, MarcinMarcinWiacekTomaszewska-Lampart, IzabellaIzabellaTomaszewska-LampartSieczkowski, BartoszBartoszSieczkowskiBartosik-Psujek, HalinaHalinaBartosik-PsujekBilik, MartaMartaBilikBandzarewicz, AnnaAnnaBandzarewiczDorobek, MalgorzataMalgorzataDorobekZielinska-Turek, JustynaJustynaZielinska-TurekNowakowska-Kotas, MartaMartaNowakowska-KotasObara, KrystianKrystianObaraUrbanowski, PawełPawełUrbanowskiBudrewicz, SlawomirSlawomirBudrewiczGuziński, MaciejMaciejGuzińskiŚwitońska, MilenaMilenaŚwitońskaRutkowska, IwonaIwonaRutkowskaSobieszak-Skura, PaulinaPaulinaSobieszak-SkuraLabuz-Roszak, Beata MBeata MLabuz-RoszakDebiec, AleksanderAleksanderDebiecStaszewski, JacekJacekStaszewskiStępień, AdamAdamStępieńZwiernik, JacekJacekZwiernikWasilewski, GrzegorzGrzegorzWasilewskiTiu, CristinaCristinaTiuTerecoasă, Elena OanaElena OanaTerecoasăRadu, Razvan AlexandruRazvan AlexandruRaduNegrila, AncaAncaNegrilaDorobat, BogdanBogdanDorobatPanea, CristinaCristinaPaneaTiu, VladVladTiuPetrescu, SimonaSimonaPetrescuOzdemir, AtillaAtillaOzdemirMahmoud, MostafaMostafaMahmoudEl-Samahy, HussamHussamEl-SamahyAbdelkhalek, HazemHazemAbdelkhalekAl-Hashel, JasemJasemAl-HashelIsmail, Ismail IbrahimIsmail IbrahimIsmailSalmeen, AthariAthariSalmeenGhoreishi, AbdorezaAbdorezaGhoreishiSabetay, Sergiu IonutSergiu IonutSabetayGross, HanaHanaGrossKlein, PiersPiersKleinAbdalkader, MohamadMohamadAbdalkaderJabbour, PascalPascalJabbourEl Naamani, KareemKareemEl NaamaniTjoumakaris, StavropoulaStavropoulaTjoumakarisAbbas, RawadRawadAbbasMohamed, Ghada AGhada AMohamedChebl, AlexAlexCheblMin, JiangyongJiangyongMinHovingh, MajestaMajestaHovinghTsai, Jenney PJenney PTsaiKhan, MuhibMuhibKhanNalleballe, KrishnaKrishnaNalleballeOnteddu, SanjeevaSanjeevaOntedduMasoud, HeshamHeshamMasoudMichael, MinaMinaMichaelKaur, NavreetNavreetKaurMaali, LaithLaithMaaliAbraham, Michael GMichael GAbrahamKhandelwal, PriyankPriyankKhandelwalBach, IvoIvoBachOng, MelodyMelodyOngBabici, DenisDenisBabiciKhawaja, Ayaz MAyaz MKhawajaHakemi, MaryamMaryamHakemiRajamani, KumarKumarRajamaniCano-Nigenda, VanessaVanessaCano-NigendaArauz, AntonioAntonioArauzAmaya, PabloPabloAmayaLlanos, NataliaNataliaLlanosArango, AkemiAkemiArangoVences, Miguel ÁngelMiguel ÁngelVencesBarrientos Guerra, Jose DominguoJose DominguoBarrientos GuerraCaetano, RaylleneRaylleneCaetanoMartins, Rodrigo TargaRodrigo TargaMartinsScollo, Sergio DanielSergio DanielScolloYalung, Patrick MaticPatrick MaticYalungNagendra, ShashankShashankNagendraGaikwad, AbhijitAbhijitGaikwadSeo, Kwon-DukKwon-DukSeoGeorgiopoulos, GeorgiosGeorgiosGeorgiopoulosNogueira, Raul GRaul GNogueiraMichel, PatrikPatrikMichel2024-10-112024-10-112023-02-14https://boris-portal.unibe.ch/handle/20.500.12422/88855BACKGROUND AND OBJECTIVES COVID-19 related inflammation, endothelial dysfunction and coagulopathy may increase the bleeding risk and lower efficacy of revascularization treatments in patients with acute ischemic stroke. We aimed to evaluate the safety and outcomes of revascularization treatments in patients with acute ischemic stroke and COVID-19. METHODS Retrospective multicenter cohort study of consecutive patients with acute ischemic stroke receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021, tested for SARS-CoV-2 infection. With a doubly-robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). RESULTS Of a total of 15128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19. 5848 (38.7%) patients received IVT-only, and 9280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted odds ratio [OR] 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour (OR 2.47; 95% CI 1.58-3.86) and 3-month mortality (OR 1.88; 95% CI 1.52-2.33).COVID-19 patients also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60). DISCUSSION Patients with acute ischemic stroke and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 treated patients. Current available data does not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in COVID-19 patients, or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring and establishing prognosis.en600 - Technology::610 - Medicine & healtharticle10.48350/1747293635181410.1212/WNL.0000000000201537